Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Physiol Rep. 2022 Jun;10(12):e15346. doi: 10.14814/phy2.15346.
Transcranial magnetic stimulation (TMS) motor mapping is a safe, non-invasive method that can be used to study corticomotor organization. Motor maps are typically acquired at rest, and comparisons to maps obtained during muscle activation have been both limited and contradictory. Understanding the relationship between functional activation of the corticomotor system as recorded by motor mapping is crucial for their use clinically and in research. The present study utilized robotic TMS paired with personalized neuro-navigation to examine the relationship between resting and active motor map measures and their relationship with motor performance. Twenty healthy right-handed participants underwent resting and active robotic TMS motor mapping of the first dorsal interosseous to 10% maximum voluntary contraction. Motor map parameters including map area, volume, and measures of map centrality were compared between techniques using paired sample tests of difference and Bland-Altman plots and analysis. Map area, volume, and hotspot magnitude were larger in the active motor maps, while map center of gravity and hotspot locations remained consistent between both maps. No associations were observed between motor maps and motor performance as measured by the Purdue Pegboard Test. Our findings support previous suggestions that maps scale with muscle contraction. Differences in mapping outcomes suggest rest and active motor maps may reflect functionally different corticomotor representations. Advanced analysis methods may better characterize the underlying neurophysiology of both types of motor mapping.
经颅磁刺激（TMS）运动映射是一种安全、非侵入性的方法，可用于研究皮质运动组织。运动图通常在休息时获得，并且与在肌肉激活期间获得的地图进行比较既有限又矛盾。了解记录的皮质运动系统功能激活与运动映射之间的关系对于它们在临床和研究中的使用至关重要。本研究利用机器人 TMS 与个性化神经导航相结合，研究静息和主动运动映射测量之间的关系及其与运动表现的关系。20 名健康的右利手参与者接受了第一个背侧间骨间肌的机器人 TMS 运动映射，达到 10%的最大自主收缩。使用配对样本差异检验、Bland-Altman 图和分析比较两种技术之间的运动图参数，包括地图面积、体积和地图中心性测量。主动运动图中的地图面积、体积和热点幅度较大，而两种地图的地图重心和热点位置保持一致。运动图与普渡钉板测试测量的运动表现之间没有观察到关联。我们的研究结果支持了之前的建议，即地图与肌肉收缩成正比。映射结果的差异表明，静息和主动运动图可能反映了功能不同的皮质运动代表。高级分析方法可能更好地描述这两种运动映射的潜在神经生理学。
