Institut Curie, Université Paris-Saclay, CNRS, UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, 91400 Orsay, France.
Phys Med. 2022 Aug;100:64-71. doi: 10.1016/j.ejmp.2022.06.010. Epub 2022 Jun 21.
Proton minibeam radiation therapy (pMBRT) is a novel therapeutic strategy that combines the normal tissue sparing of sub-millimetric, spatially fractionated beams with the improved ballistics of protons. This may allow a safe dose escalation in the tumour and has already proven to provide a remarkable increase of the therapeutic index for high-grade gliomas in animal experiments. One of the main challenges in pMBRT concerns the generation of minibeams and the implementation in a clinical environment. This article reviews the different approaches for generating minibeams, using mechanical collimators and focussing magnets, and discusses the technical aspects of the implementation and delivery of pMBRT.
质子微束放射治疗（pMBRT）是一种新的治疗策略，它将亚毫米级、空间分割的光束的正常组织保护与质子的改善弹道结合在一起。这可能允许在肿瘤中安全地增加剂量，并已在动物实验中证明为高级别脑胶质瘤提供了显著增加的治疗指数。pMBRT 的主要挑战之一是产生微束和在临床环境中实施。本文综述了使用机械准直器和聚焦磁铁产生微束的不同方法，并讨论了 pMBRT 的实施和输送的技术方面。
