Department of Obstetrics and Gynecology, National Health Insurance Service Ilsan Hospital, Goyang-si, Republic of Korea.
Korea Research and Analysis Team, National Health Insurance Service Ilsan Hospital, Goyang-si, Republic of Korea.
Sci Rep. 2022 Jun 24;12(1):10791. doi: 10.1038/s41598-022-14942-z.
The aim of this study was to examine the effect of seasonal changes on the incidence of preeclampsia (PE) in South Korea and East Asian populations, and to evaluate the relationship between upper respiratory infection (URI) during pregnancy and the development of PE. This cohort study included women who had singleton births between 2012 and 2018 in South Korea. A total of 548,080 first singleton births were analyzed, and 9311 patients (1.70%) were diagnosed with PE. Multivariate analysis showed that older age (≥ 30 years old), low income, residing in the southern part of South Korea, history of cigarette smoking, heavy drinking, higher body mass index, hypertension, or diabetes mellitus were risk factors for PE. Univariate analysis showed that URI was associated with the incidence of PE (P = 0.0294). However, this association was not statistically significant in the multivariate analysis (aOR 1.01; 95% CI 0.95-1.07). After adjusting for confounding variables, the occurrence of PE was the highest in December (aOR 1.21; 95% CI 1.10-1.34) and lowest in July and August. This study demonstrated that there are seasonal variations in the occurrence of PE in South Korea. Moreover, URI may be associated with the development of PE.
本研究旨在探讨季节变化对韩国及东亚人群先兆子痫（PE）发病率的影响，并评估妊娠期间上呼吸道感染（URI）与 PE 发展之间的关系。这项队列研究纳入了 2012 年至 2018 年期间在韩国分娩的单胎产妇。共分析了 548,080 例首次单胎分娩，其中 9311 例（1.70%）被诊断为 PE。多变量分析显示，年龄较大（≥30 岁）、收入较低、居住在韩国南部、吸烟史、酗酒、体重指数较高、高血压或糖尿病是 PE 的危险因素。单变量分析显示，URI 与 PE 的发生有关（P=0.0294）。然而，多变量分析并未显示这种关联具有统计学意义（aOR 1.01；95% CI 0.95-1.07）。在校正混杂变量后，PE 的发生在 12 月最高（aOR 1.21；95% CI 1.10-1.34），7 月和 8 月最低。本研究表明，PE 的发生在韩国存在季节性变化。此外，URI 可能与 PE 的发生有关。
