Mohamed Ahmed, Wafaie Khaled, Mohammed Hisham, Mohamed Abdelrahman Magdi Ahmed, Xinrui Wang, Vandevska-Radunovic Vaska, Yiqiang Qiao
Department of Orthodontics, Faculty of Dentistry, First affiliated hospital of Zhengzhou University, Zhengzhou, China.
Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Orthod Craniofac Res. 2023 May;26(2):163-170. doi: 10.1111/ocr.12596. Epub 2022 Jul 7.
This randomized controlled trial (RCT) aims to investigate the short-term effects of chlorhexidine mouthwash (MW) on gingival health surrounding orthodontic miniscrew implants (OMIs) and their overall survivability.
Thirty-two participants (mean age, 22.8 years) undergoing fixed orthodontic appliance treatment after maxillary premolar extraction were randomly allocated in a parallel fashion to either receive (1) MW with an active component of chlorhexidine or (2) a placebo. Each participant received two maxillary buccal OMIs for anchorage reinforcement purposes. Participants were assessed for their gingival oral health status around all inserted OMIs and had their OMI survivability recorded at three time points; T1 = 1 month, T2 = 3 months, and T3 = 6 months after OMI placement. A Kaplan-Meier plot was used to estimate the survival function of OMIs.
All randomized participants completed the follow-up period. In terms of gingival oral health, there were no statistically significant differences at any time point between the chlorhexidine MW group and the placebo-controlled group (P > .05). One OMI was lost in the chlorhexidine MW group and another two OMIs in the control group. There was no significant difference between both groups in terms of survivability (P = .585).
The use of chlorhexidine MW does not seem to have a significant clinical impact on gingival health around OMIs or their survivability in this pilot study.
本随机对照试验（RCT）旨在研究洗必泰漱口水（MW）对正畸微螺钉种植体（OMIs）周围牙龈健康及其总体存活率的短期影响。
32名（平均年龄22.8岁）在上颌前磨牙拔除后接受固定正畸矫治器治疗的参与者被随机平行分配，以接受（1）含洗必泰活性成分的MW或（2）安慰剂。每位参与者接受两颗上颌颊侧OMIs用于加强支抗。评估参与者所有植入OMIs周围的牙龈口腔健康状况，并在三个时间点记录OMIs的存活率；T1 = 植入OMI后1个月，T2 = 3个月，T3 = 6个月。采用Kaplan-Meier图估计OMIs的生存函数。
所有随机分组的参与者均完成了随访期。在牙龈口腔健康方面，洗必泰MW组与安慰剂对照组在任何时间点均无统计学显著差异（P > .05）。洗必泰MW组有一颗OMI丢失，对照组有另外两颗OMIs丢失。两组在存活率方面无显著差异（P = .585）。
在本初步研究中，使用洗必泰MW似乎对OMIs周围的牙龈健康或其存活率没有显著的临床影响。
