Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii, USA.
Hawai'i Pacific Health Medical Group, Honolulu, Hawaii, USA.
J Pediatric Infect Dis Soc. 2022 Oct 25;11(10):452-453. doi: 10.1093/jpids/piac050.
Varicella is a highly contagious disease caused by Varicella-zoster virus (VZV). The American College of Obstetricians and Gynecologists (ACOG) adopted the routine administration of varicella vaccine to varicella non-immune mothers postpartum before leaving the facility per the Advisory Committee in Immunization Practices (ACIP) recommendation of Varicella prevention. While the vaccine is well-tolerated, a live attenuated vaccine has the potential to cause clinical symptoms and complications, including rash. Secondary transmission of the vaccine virus from healthy persons is rare. Only 13 confirmed cases of secondary transmission from 11 immunocompetent vaccine recipients have been reported. We report the confirmed case of extensive neonatal varicella disease in a neonate after exposure to a vaccine varicella rash that developed after maternal postpartum vaccination.
水痘是由水痘-带状疱疹病毒（VZV）引起的高度传染性疾病。美国妇产科医师学会（ACOG）根据免疫实践咨询委员会（ACIP）关于预防水痘的建议，在产妇离开医疗机构前对水痘非免疫的母亲进行常规的水痘疫苗接种。虽然该疫苗具有良好的耐受性，但减毒活疫苗有可能引起临床症状和并发症，包括皮疹。健康人传播疫苗病毒的情况很少见。从 11 名免疫功能正常的疫苗接种者中仅报告了 13 例确认的疫苗病毒二次传播病例。我们报告了一例产妇产后接种疫苗后出现皮疹，随后新生儿暴露于该皮疹后发生广泛新生儿水痘疾病的确诊病例。
