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新生儿 ICU 中的水痘病例是由水痘疫苗 Oka 株引起的。

Varicella in the neonatal ICU due to the Varicella vaccine Oka strain.

机构信息

Department of Pediatrics, Columbia University Irving Medical Center, New York City, New York, USA.

NewYork-Presbyterian Morgan Stanley Children's Hospital, New York City, New York, USA.

出版信息

J Neonatal Perinatal Med. 2023;16(1):179-182. doi: 10.3233/NPM-221031.

DOI:10.3233/NPM-221031
PMID:36744349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10346796/
Abstract

BACKGROUND

Varicella vaccination of non-immune post-partum women is recommended to reduce the risk of chickenpox in mothers and their infants. Though rare, transmission of the varicella vaccine strain vOka can occur from recent vaccinees to non-immune contacts who usually develop mild chickenpox.

METHODS/RESULTS: Here we describe an infant hospitalized in the neonatal ICU with vaccine-strain varicella due to transmission from their mother who received the varicella vaccine post-partum. We describe the infection prevention and control strategies implemented to prevent further transmission.

CONCLUSION

Vaccine-strain varicella transmission from mother to infant is a rare event and its occurrence in the neonatal ICU setting can be challenging. Anticipatory guidance for mothers vaccinated in the postpartum period and support of parents of an infected infant are recommended.

摘要

背景

为降低产妇及其婴儿患水痘的风险,推荐对非免疫的产后妇女进行水痘疫苗接种。虽然罕见,但水痘疫苗株 vOka 可由近期接种者传播给无免疫力的接触者,这些接触者通常会出现轻度水痘。

方法/结果:在此,我们描述了一例因母亲产后接种水痘疫苗而从其母亲处感染疫苗株水痘的新生儿重症监护病房住院婴儿。我们描述了为防止进一步传播而实施的感染预防和控制策略。

结论

疫苗株水痘由母亲传播给婴儿的情况较为罕见,而其在新生儿重症监护病房的发生可能具有挑战性。建议对产后接种疫苗的母亲提供预期指导,并为感染婴儿的父母提供支持。

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本文引用的文献

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J Pediatric Infect Dis Soc. 2022 Oct 25;11(10):452-453. doi: 10.1093/jpids/piac050.
2
Transmission of Vaccine-Strain Varicella-Zoster Virus: A Systematic Review.疫苗株水痘带状疱疹病毒传播:系统评价。
Pediatrics. 2019 Sep;144(3). doi: 10.1542/peds.2019-1305.
3
A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR(-) B cells.一种反复出现的显性负 E47 突变导致无丙种球蛋白血症和 BCR(-) B 细胞。
J Clin Invest. 2013 Nov;123(11):4781-5. doi: 10.1172/JCI71927.
4
Neonatal vaccine-strain varicella-zoster virus infection 22 days after maternal postpartum vaccination.产妇产后接种疫苗 22 天后新生儿疫苗株水痘-带状疱疹病毒感染。
Pediatr Infect Dis J. 2012 Sep;31(9):977-9. doi: 10.1097/INF.0b013e31825d2a1b.
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Novel genetic variation identified at fixed loci in ORF62 of the Oka varicella vaccine and in a case of vaccine-associated herpes zoster.在 Oka 水痘疫苗的 ORF62 中和一例疫苗相关性带状疱疹病例中,鉴定到固定位点的新型遗传变异。
J Clin Microbiol. 2012 May;50(5):1533-8. doi: 10.1128/JCM.06630-11. Epub 2012 Feb 29.
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Semin Fetal Neonatal Med. 2009 Aug;14(4):209-17. doi: 10.1016/j.siny.2008.11.008. Epub 2008 Dec 19.
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