Department of Preventive Medicine, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China; Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazardsa, Hengyang Medical School, University of South China, Hengyang, China.
Department of Preventive Medicine, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China; Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazardsa, Hengyang Medical School, University of South China, Hengyang, China.
Acta Histochem. 2022 Aug;124(6):151916. doi: 10.1016/j.acthis.2022.151916. Epub 2022 Jun 22.
The N6-methyladenosine (mA) refers to the methylation of the N6 position of adenosine of RNA adenine. The modification of mA is one of the most abundant epigenetic modifications in eukaryotic mRNA and non-coding RNA and is controlled by methyltransferases and demethylases. The biological mechanism and significance of mA have been discovered with the development of mA sequencing. Various mA complex components regulate the function of mA on mRNA. Methyltransferase-like 3 (METTL3) is one of the earliest identified mA methyltransferases which regulate the functions of mA. A large number of studies have shown that METTL3 establishes a cross-talk with tumor cells and development of various human diseases. In this review, we will briefly elaborate on the role of METTL3 in biological function, epithelial-mesenchymal transition (EMT), inflammatory response and sensitivity to the resistance of chemo radiotherapies. The underlying molecular mechanism demonstrated by METTL3 may provide a possible target for treating and diagnosing human diseases.
N6-甲基腺苷（m6A）是指 RNA 腺嘌呤中腺苷的 N6 位发生甲基化修饰。m6A 修饰是真核生物 mRNA 和非编码 RNA 中最丰富的表观遗传修饰之一，由甲基转移酶和去甲基酶调控。m6A 测序的发展揭示了 m6A 的生物学机制和意义。各种 m6A 复合物成分调节 m6A 在 mRNA 上的功能。甲基转移酶样蛋白 3（METTL3）是最早被鉴定的 m6A 甲基转移酶之一，它调节 m6A 的功能。大量研究表明，METTL3 与肿瘤细胞和各种人类疾病的发生发展建立了交叉对话。在这篇综述中，我们将简要阐述 METTL3 在生物学功能、上皮-间充质转化（EMT）、炎症反应以及对化疗放疗耐药性的敏感性中的作用。METTL3 所揭示的潜在分子机制可能为人类疾病的治疗和诊断提供一个可能的靶点。
