Sorensen K, Brodbeck U, Rasmussen A G, Norgaard-Pedersen B
Prenat Diagn. 1987 Feb;7(2):75-9. doi: 10.1002/pd.1970070203.
We have investigated the occurrence of acetylcholinesterase (AChE) (E.C. 3.1.1.7) in fetal serum, amniotic fluid and maternal serum using an immuno-chemical assay-technique employing both polyclonal and monoclonal antibodies. Fetal serum had increased amounts of AChE, which is due to an increase in the 10.5S form of the enzyme. This form was also found in amniotic fluids of pregnancies with a fetal neural tube defect (NTD), but not in normal amniotic fluid. The increase in amniotic fluid AChE was however, not reflected in the maternal serum.
我们采用使用多克隆和单克隆抗体的免疫化学分析技术，研究了胎儿血清、羊水和母体血清中乙酰胆碱酯酶（AChE）（E.C. 3.1.1.7）的存在情况。胎儿血清中AChE含量增加，这是由于该酶10.5S形式的增加所致。这种形式也在患有胎儿神经管缺陷（NTD）的妊娠羊水内发现，但在正常羊水中未发现。然而，羊水AChE的增加并未反映在母体血清中。
