Department of Cell and Molecular Pharmacology and Experimental Therapeutics and MUSC, Proteomics Center, Medical University of South Carolina , Charleston , SC , USA.
Expert Rev Proteomics. 2019 Aug;16(8):665-680. doi: 10.1080/14789450.2019.1645604. Epub 2019 Jul 25.
: For decades, the role of glycans and glycoproteins in the progression of breast cancer and other cancers have been evaluated. Through extensive studies focused on elucidating the biological functions of glycosylation, researchers have been able to implicate alterations in these functions to tumor formation and metastasis. : In this review, we summarize how changes in glycosylation are associated with tumorigenesis, with emphasis on breast cancers. An overview of the changes in N-linked and O-linked glycans associated with breast cancer tumors and biofluids are described. Recent advances in glycomics are emphasized in the context of continuing to decipher the glycosylation changes associated with breast cancer progression. : While changes in glycosylation have been studied in breast cancer for many years, the clinical relevance of these studies has been limited. This reflects the inherent biological and clinical heterogeneity of breast cancers. Glycomics analysis lags behind the advances in genomics and proteomics, but new approaches are emerging. A summary of known glycosylation changes associated with breast cancer is necessary to implement new findings in the context of clinical outcomes and therapeutic strategies. A better understanding of the dynamics of tumor and immune glycosylation is critical to improving emerging immunotherapeutic treatments.
几十年来，人们一直在研究聚糖和糖蛋白在乳腺癌和其他癌症进展中的作用。通过广泛研究糖基化的生物学功能，研究人员能够将这些功能的改变与肿瘤的形成和转移联系起来。
在这篇综述中，我们总结了糖基化的变化如何与肿瘤发生相关，重点是乳腺癌。描述了与乳腺癌肿瘤和生物流体相关的 N 连接和 O 连接聚糖变化的概述。强调了糖组学的最新进展，以继续破译与乳腺癌进展相关的糖基化变化。
虽然糖基化的变化在乳腺癌中已经研究了很多年，但这些研究的临床相关性有限。这反映了乳腺癌固有的生物学和临床异质性。糖组学分析落后于基因组学和蛋白质组学的进展，但新的方法正在出现。总结与乳腺癌相关的已知糖基化变化对于将新发现应用于临床结果和治疗策略是必要的。更好地了解肿瘤和免疫糖基化的动态对于改善新兴的免疫治疗至关重要。
