Department of Clinical Nutrition, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, PR China.
Department of Pain Management, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, PR China.
J Affect Disord. 2022 Sep 15;313:151-157. doi: 10.1016/j.jad.2022.06.046. Epub 2022 Jun 24.
Depression is one of the most common diseases in the world, and severe depression is the second leading cause of disability in the world. However, the relationship between depressive symptoms and body mass index (BMI) is still unclear. The purpose of this study was to explore the relationship between BMI and depressive symptoms.
We conducted a cross-sectional study involving 35,407 participants, all data collected from NHANES 2005-2018. A multivariable logistic regression model was used to analyze the relationship between depressive symptoms (outcome variables) and BMI levels (independent variables). The Patient Health Questionnaire (PHQ-9) was the primary measure of depressive symptoms. We also performed sensitivity analyses, including multiple sensitivity analyses.
After adjusting for covariates, the ORS (95 % CI) of depressive symptoms from the lowest to the highest levels of BMI were 1.14 (1.00-1.30), 1.00 (Reference), 1.19 (1.05-1.35) and 1.45 (1.29-1.64), respectively. However, stratified analysis and sensitivity analysis showed that there was no U-shaped relationship between non-Hispanic black race and depressive symptoms.
Self-reporting questionnaire may lead to recall bias or reporting bias; Cross-sectional studies failed to verify causality.
There is a U-shaped relationship between depression and BMI. However, no such relationship was found among non-Hispanic blacks. More researches are needed to confirm the relationship between weight and depression, as well as the causal relationship between them.
抑郁症是世界上最常见的疾病之一，重度抑郁症是世界上导致残疾的第二大原因。然而，抑郁症状与体重指数（BMI）之间的关系仍不清楚。本研究旨在探讨 BMI 与抑郁症状之间的关系。
我们进行了一项横断面研究，纳入了 35407 名参与者，所有数据均来自 NHANES 2005-2018 年。采用多变量逻辑回归模型分析抑郁症状（因变量）与 BMI 水平（自变量）之间的关系。患者健康问卷（PHQ-9）是抑郁症状的主要测量工具。我们还进行了敏感性分析，包括多次敏感性分析。
调整了协变量后，BMI 水平从最低到最高的抑郁症状的 ORS（95%CI）分别为 1.14（1.00-1.30）、1.00（参考）、1.19（1.05-1.35）和 1.45（1.29-1.64）。然而，分层分析和敏感性分析显示，非西班牙裔黑人种族与抑郁症状之间没有 U 型关系。
自报告问卷可能导致回忆偏倚或报告偏倚；横断面研究无法验证因果关系。
抑郁症状与 BMI 之间存在 U 型关系。然而，在非西班牙裔黑人中未发现这种关系。需要进一步的研究来确认体重与抑郁之间的关系以及它们之间的因果关系。
