Liu Hangyu, Zhi Jin, Zhang Chuzhao, Huang Shiyi, Ma Yang, Luo Dandan, Shi Lungang
The Second Affiliated Hospital of Shantou University Medical College, North Dongxia Road, Shantou 515041, Guangdong, China.
Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, Shanghai 201100, China.
J Affect Disord. 2024 Apr 1;350:49-57. doi: 10.1016/j.jad.2024.01.104. Epub 2024 Jan 12.
Depressive symptoms are strongly associated with the development of various diseases and are one of the leading causes of disability in the world. However, the relationship between weight-adjusted waist index (WWI) and depressive symptoms has not been studied. This study aimed to assess the relationship between depressive symptoms and WWI.
This study took NHANES data from 2005 to 2018 with 32,374 participants. Depressive symptoms were measured by a questionnaire (PHQ-9).WWI was determined by dividing the square root of waist circumference (cm) by weight (kg). Multivariate logistic regression models, smoothed curve fitting, and weighted generalized additive model (GAM) regression were used to examine the relationship between depressive symptoms and WWI, BMI, and waist circumference. Subgroup analyses and interaction tests were also performed.
In fully adjusted models, the OR (95 % CI) for WWI and depressive symptoms with WWI, BMI, and waist circumference were 1.18 (1.05, 1.34), BMI 1.01 (1.00, 1.02, 1.01 (1.00, 1.01), respectively. Participants in the highest quartile (Q4) had a 49 % higher depressive symptoms compared to those in the lowest quartile (Q1) (OR = 1.49, 95 % CI:1.14-1.96). Subgroup analyses and interaction tests showed a stable relationship between depressive symptoms and WWI.
It is difficult to determine a causal relationship between the two; questionnaire collection may be somewhat biased; CONCLUSIONS: WWI was positively associated with depressive symptoms. This association was stronger than BMI and waist circumference. However, this relationship was stable. This study emphasizes the potential utility of WWI in preventing depressive symptoms and improving prognosis in the population.
抑郁症状与多种疾病的发生密切相关，是全球残疾的主要原因之一。然而，体重调整腰围指数（WWI）与抑郁症状之间的关系尚未得到研究。本研究旨在评估抑郁症状与WWI之间的关系。
本研究采用2005年至2018年美国国家健康与营养检查调查（NHANES）的数据，共有32374名参与者。抑郁症状通过问卷调查（PHQ-9）进行测量。WWI通过腰围（厘米）的平方根除以体重（千克）来确定。使用多变量逻辑回归模型、平滑曲线拟合和加权广义相加模型（GAM）回归来检验抑郁症状与WWI、体重指数（BMI）和腰围之间的关系。还进行了亚组分析和交互作用检验。
在完全调整模型中，WWI以及伴有WWI、BMI和腰围的抑郁症状的比值比（OR，95%置信区间）分别为1.18（1.05，1.34）、BMI为1.01（1.00，1.02）、腰围为1.01（1.00，1.01）。最高四分位数（Q4）的参与者比最低四分位数（Q1）的参与者抑郁症状高49%（OR = 1.49，95%置信区间：1.14 - 1.96）。亚组分析和交互作用检验显示抑郁症状与WWI之间存在稳定关系。
难以确定两者之间的因果关系；问卷调查收集可能存在一定偏差；
WWI与抑郁症状呈正相关。这种关联比BMI和腰围更强。然而，这种关系是稳定的。本研究强调了WWI在预防人群抑郁症状和改善预后方面的潜在效用。
