Bermúdez-Rattoni F, Coburn K L, Fernández J, Chávez A F, Garcia J
Pharmacol Biochem Behav. 1987 Mar;26(3):553-9. doi: 10.1016/0091-3057(87)90165-1.
Limbic cholinergic activity is critically involved in the retention of learned aversions tasks. The purpose of these experiments was to assess the role of cholinergic mechanisms of the dorsal hippocampus in the acquisition of both odor and potentiated odor aversions through taste aversion. Cholinergic activity was increased by physostigmine (Phys). When Phys was applied before the presentation of an odor-taste compound during acquisition, the potentiation of odor-aversion was disrupted, while taste aversion was left intact. When hippocampal cholinergic activity was reduced with the muscarinic antagonist scopolamine (Scop), enhancement of potentiated odor aversion was observed, again with no effect on taste aversion. Moreover, when Phys was applied before an odor alone it also disrupted odor avoidance in two different odor tests conditioning situations, i.e., odor was followed immediately by lithium chloride or foot shock. Neither Scop nor Phys had any effect on taste or potential odor aversions when applied to fronto-parietal cortex. These results suggest that cholinergic activity of the hippocampus is involved in the acquisition of odor aversion conditioning.
边缘胆碱能活性在习得性厌恶任务的记忆中起着关键作用。这些实验的目的是通过味觉厌恶来评估背侧海马体胆碱能机制在气味和增强气味厌恶习得中的作用。毒扁豆碱（Phys）可增加胆碱能活性。在习得过程中，在呈现气味 - 味觉复合物之前应用Phys时，气味厌恶的增强被破坏，而味觉厌恶保持不变。当用毒蕈碱拮抗剂东莨菪碱（Scop）降低海马胆碱能活性时，观察到增强气味厌恶的增强，同样对味觉厌恶没有影响。此外，当在单独的气味之前应用Phys时，它也会在两种不同的气味测试条件下破坏气味回避，即气味后立即给予氯化锂或足部电击。当应用于额顶叶皮层时，Scop和Phys对味觉或潜在气味厌恶均无任何影响。这些结果表明，海马体的胆碱能活性参与了气味厌恶条件反射的习得。
