Emergency Medicine Department, Attikon University Hospital, Athens, Greece.
Department of Cardiology, LAIKO General Hospital, Athens, Greece.
Drugs Aging. 2022 Jul;39(7):551-557. doi: 10.1007/s40266-022-00955-w. Epub 2022 Jun 27.
Antihypertensive drugs are among the most documented regimens worldwide with an overall survival and cardioprotective benefit. However, there is evidence that they cause symptoms of orthostatic hypotension (i.e., dizziness and syncope) placing patients at risk for falls and fall-related injuries such as bone fractures. Moreover, it seems that they might impact bone metabolism and architecture impairing bone health. The aim of this review was to summarize the accumulative literature exploring any potential association between several antihypertensive medications including diuretics, renin-angiotensin-aldosterone system inhibitors, beta-blockers and calcium channel blockers and the risk of fractures.
抗高血压药物是全球记录最完备的治疗方案之一，具有整体生存和心脏保护益处。然而，有证据表明，它们会引起直立性低血压（即头晕和晕厥）症状，使患者面临跌倒和跌倒相关伤害（如骨折）的风险。此外，它们似乎可能影响骨骼代谢和结构，损害骨骼健康。本综述的目的是总结积累的文献，探讨包括利尿剂、肾素-血管紧张素-醛固酮系统抑制剂、β受体阻滞剂和钙通道阻滞剂在内的几种抗高血压药物与骨折风险之间的潜在关联。
