Margiana Ria, Hammid Ali Thaeer, Ahmad Irfan, Alsaikhan Fahad, Turki Jalil Abduladheem, Tursunbaev Farkhod, Umar Fadilah, Romero Parra Rosario Mireya, Fakri Mustafa Yasser
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Crit Rev Anal Chem. 2024;54(3):617-632. doi: 10.1080/10408347.2022.2091920. Epub 2022 Jun 26.
In today's world, Parkinson's disease (PD) has been introduced as a long-term degenerative disorder of the central nervous system which mainly affects approximately more than ten million people worldwide. The vast majority of diagnostic methods for PD have operated based on conventional sensing platforms, while the traditional laboratory tests are not efficient for diagnosis of PD in the early stage due to symptoms of this common neurodegenerative syndrome starting slowly. The advent of the aptasensor has revolutionized the early-stage diagnosis of PD by measuring related biomarkers due to the myriad advantages of originating from aptamers which can be able to sensitive and selective capture various types of related biomarkers. The progress of numerous sensing platforms and methodologies in terms of biosensors based on aptamer application for PD diagnosis has revealed promising results. In this review, we present the latest developments in myriad types of aptasensors for the determination of related PD biomarkers. Working strategies, advantages and limitations of these sensing approaches are also mentioned, followed by prospects and challenges.
在当今世界，帕金森病（PD）已被确认为一种中枢神经系统的长期退行性疾病，全球约有一千多万人受其影响。绝大多数帕金森病的诊断方法都是基于传统传感平台进行的，而由于这种常见神经退行性综合征的症状发展缓慢，传统实验室检测在帕金森病早期诊断中效率不高。适配体传感器的出现彻底改变了帕金森病的早期诊断，它通过测量相关生物标志物来实现，这得益于源自适配体的众多优势，适配体能够灵敏且选择性地捕获各种相关生物标志物。基于适配体应用于帕金森病诊断的生物传感器，众多传感平台和方法学的进展已显示出令人鼓舞的结果。在这篇综述中，我们展示了用于测定帕金森病相关生物标志物的各种类型适配体传感器的最新进展。还提到了这些传感方法的工作策略、优点和局限性，随后是前景和挑战。
