Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Biosens Bioelectron. 2020 Mar 15;152:112018. doi: 10.1016/j.bios.2020.112018. Epub 2020 Jan 13.
Heart disease (especially myocardial infarction (MI)) and cancer are major causes of death. Recently, aptasensors with the applying of different nanostructures have been able to provide new windows for the early and inexpensive detection of these deadly diseases. Early, inexpensive, and accurate diagnosis by portable devices, especially aptasensors can increase the likelihood of survival as well as significantly reduce the cost of treatment. In this review, recent studies based on the designed aptasensors for the diagnosis of these diseases were collected, ordered, and reviewed. The biomarkers for the diagnosis of each disease were discussed separately. The primary constituent elements of these aptasensors including, analyte, aptamer sequence, type of nanostructure, diagnostic technique, analyte detection range, and limit of detection (LOD), were evaluated and compared.
心脏病（尤其是心肌梗死 (MI)）和癌症是主要的死亡原因。最近，基于不同纳米结构的适体传感器能够为这些致命疾病的早期和廉价检测提供新的窗口。通过便携式设备进行早期、廉价和准确的诊断，特别是适体传感器，可以提高存活率并显著降低治疗成本。在这篇综述中，收集、整理和回顾了基于设计的适体传感器用于这些疾病诊断的最新研究。分别讨论了每种疾病的诊断生物标志物。评估并比较了这些适体传感器的主要组成部分，包括分析物、适体序列、纳米结构类型、诊断技术、分析物检测范围和检测限 (LOD)。
