Alomari Mohammad, Garg Pankaj, Yazji John H, Wadiwala Ishaq J, Alamouti-Fard Emad, Hussain Md Walid Akram, Elawady Mohamed S, Jacob Samuel
Cardiothoracic Surgery, Mayo Clinic, Jacksonville, USA.
Colorectal Surgery, Mayo Clinic, Jacksonville, USA.
Cureus. 2022 Jun 24;14(6):e26281. doi: 10.7759/cureus.26281. eCollection 2022 Jun.
The scarcity of donor hearts continues to be a challenge in transplants for advanced heart failure patients. With an increasing number of patients on the waiting list for a heart transplant, the discrepancy in the number between donors and recipients is gradually increasing and poses a new challenge that plagues the healthcare systems when it comes to the heart. Several technologies have been developed to expand the donor pool in recent years. One such method is the organ care system (OCS). The standard method of organ preservation is the static cold storage (SCS) method which allows up to four hours of safe preservation of the heart. However, beyond four hours of cold ischemia, the incidence of primary graft dysfunction increases significantly. OCS keeps the heart perfused close to the physiological state beyond the four hours with superior results, which allows us to travel further and longer distances, leading to expansion in the donor pool. In this review, we discuss the OCS system, its advantages, and shortcomings.
对于晚期心力衰竭患者的心脏移植而言，供体心脏的稀缺仍是一项挑战。随着越来越多的患者加入心脏移植等待名单，供体与受体数量之间的差距逐渐增大，给心脏相关的医疗系统带来了新的困扰。近年来，人们开发了多种技术来扩大供体库。器官护理系统（OCS）就是其中一种方法。器官保存的标准方法是静态冷藏（SCS）法，该方法可使心脏安全保存长达4小时。然而，冷缺血超过4小时后，原发性移植物功能障碍的发生率会显著增加。OCS能使心脏在4小时后仍接近生理状态地持续灌注，效果更佳，这使我们能够运输到更远的地方、更长的距离，从而扩大了供体库。在本综述中，我们将讨论OCS系统及其优缺点。
