Kinghorn E W, Fleming D E, Anderson R H
Physiol Behav. 1987;39(3):297-301. doi: 10.1016/0031-9384(87)90225-3.
Photically evoked after-discharge (PhAD) bursting was examined in albino rats following either bilateral or unilateral dorsal frontal lesions. The initial effect of either type of frontal lesion was to significantly suppress PhAD occurrence. However, after repeated exposure to the PhAD recording environment no difference could be seen between the lesioned and control animals. In addition, no difference in PhAD could be detected between the two visual cortices in any of the groups. Spontaneous alternation and open-field activity were also tested. Both frontally lesioned groups of animals were significantly more active than control animals in the initial stages of testing. These findings indicate that the frontal cortex can inhibit brain stem mechanisms which are responsible for behavioral arousal and the modulation of hypersynchronous bursting in the cortex. However, because no difference was seen between the two visual cortices in any of the groups, it is suggested that this mechanism is not a strictly unilateral mechanism.
在双侧或单侧背侧额叶损伤后的白化大鼠中，研究了光诱发后放电（PhAD）爆发。两种类型的额叶损伤的初始效应是显著抑制PhAD的发生。然而，在反复暴露于PhAD记录环境后，损伤动物和对照动物之间没有差异。此外，在任何组中，两个视皮层之间的PhAD没有差异。还测试了自发交替和旷场活动。在测试的初始阶段，两个额叶损伤组的动物都比对照动物明显更活跃。这些发现表明，额叶皮层可以抑制负责行为觉醒和皮层中超同步爆发调节的脑干机制。然而，由于在任何组中两个视皮层之间都没有差异，因此表明这种机制不是严格的单侧机制。
