Kinghorn E W, Fleming D E
Physiol Behav. 1985 Aug;35(2):261-5. doi: 10.1016/0031-9384(85)90347-6.
Photically evoked after-discharge (PhAD) bursting was examined in lightly restrained albino rats following frontal and mid-cortical lesions. The initial effect of dorsal frontal lesions was to significantly suppress PhAD occurrence. Spontaneous activity as measured on an open-field arena was examined as a second variable. Frontally lesioned animals were significantly more active than mid-cortically lesioned and non-lesioned control animals in the initial stages of behavioral testing. These results indicate that the frontal cortex has an inhibitory influence on reticular formation (rf) arousal mechanisms which are responsible for behavioral arousal and the modulation of hypersynchronous burst-like phenomena occurring at the level of the cortex.
在轻度束缚的白化大鼠中，研究了额叶和皮质中部损伤后光诱发的后放电（PhAD）爆发。额叶背侧损伤的初始效应是显著抑制PhAD的发生。作为第二个变量，检测了在旷场实验中测量的自发活动。在行为测试的初始阶段，额叶损伤的动物比皮质中部损伤和未损伤的对照动物明显更活跃。这些结果表明，额叶皮质对网状结构（rf）的觉醒机制具有抑制作用，网状结构的觉醒机制负责行为觉醒以及皮质水平上发生的超同步爆发样现象的调节。
