Wu Shang-Chuen, Kamili Nourine A, Dias-Baruffi Marcelo, Josephson Cassandra D, Rathgeber Matthew F, Yeung Melissa Y, Lane William J, Wang Jianmei, Jan Hau-Ming, Rakoff-Nahoum Seth, Cummings Richard D, Stowell Sean R, Arthur Connie M
Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Department of Clinical Analysis, Toxicology, and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
iScience. 2022 May 30;25(7):104482. doi: 10.1016/j.isci.2022.104482. eCollection 2022 Jul 15.
Adaptive immunity can target a nearly infinite range of antigens, yet it is tempered by tolerogenic mechanisms that limit autoimmunity. Such immunological tolerance, however, creates a gap in adaptive immunity against microbes decorated with self-like antigens as a form of molecular mimicry. Our results demonstrate that the innate immune lectin galectin-7 (Gal-7) binds a variety of distinct microbes, all of which share features of blood group-like antigens. Gal-7 binding to each blood group expressing microbe, including strains of , , and , results in loss of microbial viability. Although Gal-7 also binds red blood cells (RBCs), this interaction does not alter RBC membrane integrity. These results demonstrate that Gal-7 recognizes a diverse range of microbes, each of which use molecular mimicry while failing to induce host cell injury, and thus may provide an innate form of immunity against molecular mimicry.
适应性免疫能够针对几乎无限范围的抗原，但它受到限制自身免疫的耐受机制的调节。然而，这种免疫耐受在针对以分子模拟形式带有类自身抗原的微生物的适应性免疫中造成了缺口。我们的结果表明，先天性免疫凝集素半乳糖凝集素-7（Gal-7）能结合多种不同的微生物，所有这些微生物都具有类血型抗原的特征。Gal-7与每种表达血型的微生物结合，包括 、 、 和 的菌株，都会导致微生物活力丧失。虽然Gal-7也能结合红细胞（RBC），但这种相互作用不会改变红细胞膜的完整性。这些结果表明，Gal-7能识别多种微生物，每种微生物都利用分子模拟但不会诱导宿主细胞损伤，因此可能提供一种针对分子模拟的先天性免疫形式。
