SARS-CoV-2 受体结合域优先识别血型 A。
The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A.
机构信息
Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Center for Transfusion Medicine and Cellular Therapies, Emory University School of Medicine, Atlanta, GA; and.
出版信息
Blood Adv. 2021 Mar 9;5(5):1305-1309. doi: 10.1182/bloodadvances.2020003259.
Abstract
The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens. SARS-CoV-2 RBD binds the blood group A expressed on respiratory epithelial cells, directly linking blood group A and SARS-CoV-2.
摘要
SARS-CoV-2 的 RBD 与已知结合血型抗原的古老凝集素家族具有序列相似性。SARS-CoV-2 的 RBD 结合呼吸道上皮细胞上表达的血型 A，直接将血型 A 与 SARS-CoV-2 联系起来。
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