Mo Haishan, Lin Xu, Liu Ming, Liang Hui
Department of General Surgery, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, People's Republic of China.
College of Oceanography, Hohai University, Nanjing, People's Republic of China.
Infect Drug Resist. 2022 Jun 18;15:3173-3177. doi: 10.2147/IDR.S363019. eCollection 2022.
Cephalosporins and azithromycin are clinical antibiotics used to treat infections. Co-resistance to cephalosporins and azithromycin has been observed in some , but it has only rarely been reported in species. In this study, we isolated a cephalosporin- and azithromycin-resistant strain, VFN3, from hospital sewage. Whole-genome sequencing results showed that the strain VFN3 possesses an IncA/C2 plasmid, pVFN3-blaOXA-193K. This conjugative plasmid carries several clinically relevant drug resistance genes, including (A) and . We also found that in the strain VFN3, (A) and are surrounded by insertion sequences and class I integrons, respectively. These data suggest that mobile elements mediate the transfer of (A) and . This is the first reported species that possesses an (A)- and -bearing conjugative plasmid. The emergence of this conjugative multi-drug-resistance plasmid is of great concern to public health.
头孢菌素和阿奇霉素是用于治疗感染的临床抗生素。在某些情况下已观察到对头孢菌素和阿奇霉素的共同耐药性，但在[具体物种]中很少有报道。在本研究中，我们从医院污水中分离出一株对头孢菌素和阿奇霉素耐药的[具体物种]菌株VFN3。全基因组测序结果表明，菌株VFN3拥有一个IncA/C2质粒，即pVFN3-blaOXA-193K。这个接合质粒携带几个临床相关的耐药基因，包括（A）和[具体基因]。我们还发现，在菌株VFN3中，（A）和[具体基因]分别被插入序列和I类整合子包围。这些数据表明，移动元件介导了（A）和[具体基因]的转移。这是首次报道的拥有携带（A）和[具体基因]的接合质粒的[具体物种]。这种接合性多药耐药质粒的出现引起了公共卫生的极大关注。
