Rush Department of Neurological Sciences, Rush University Medical Center, 1725 W Harrison St, Chicago, IL 60612, USA.
Rush Alzheimer's Disease Center, 1750 W Harrison St, Chicago, IL 60612, USA.
J Nutr Sci. 2022 Jun 9;11:e44. doi: 10.1017/jns.2022.38. eCollection 2022.
The present study examines the association of diet with depressive symptoms among stroke survivors from a community cohort of older adults. Depression is common after stroke. A healthy diet has previously been associated with fewer depressive symptoms in older individuals, but it is unknown if this effect is also seen in stroke survivors. Eighty-six participants from the Memory and Aging Project with a history of stroke at their study baseline enrolment, complete dietary data and two or more assessments for depression were included in this observational prospective cohort analysis. Depressive symptoms were assessed annually with a 10-item version of the Center for Epidemiologic Studies Depression scale. Diet was assessed using a validated food-frequency questionnaire administered at baseline. Diet scores were based on analysis of participants' reported intakes of 144 food items. A generalised estimating equation (GEE) model was applied to examine the association of diet score with depressive symptoms. The study participants had a mean age of 82 ± 7⋅17 years and 14⋅42 ± 2⋅61 years of education, and 82⋅56 % were female. Western diet score was positively associated with depressive symptoms over time (diet score tertile 3 . tertile 1: = 0⋅22, se = 0⋅09, = 0⋅02; for trend = 0⋅022). Interaction with sex suggested a stronger effect in females. A Western diet was associated with more post-stroke depressive symptoms, suggesting nutrition is important not only for reducing cerebrovascular risk, but for protecting post-stoke mental health as well.
本研究考察了社区老年人群卒中幸存者饮食与抑郁症状之间的关联。卒中后常见抑郁。既往研究表明，健康饮食与老年人较少的抑郁症状相关，但在卒中幸存者中是否也存在这种关联尚不清楚。在这项观察性前瞻性队列分析中，共有 86 名来自记忆与衰老项目的参与者，在研究基线时患有卒中，完成了饮食数据和两次或两次以上的抑郁评估。抑郁症状每年通过流行病学研究中心抑郁量表的 10 项版本进行评估。饮食通过基线时进行的经过验证的食物频率问卷进行评估。饮食评分基于参与者报告的 144 种食物摄入量的分析。广义估计方程（GEE）模型用于检查饮食评分与抑郁症状之间的关联。研究参与者的平均年龄为 82 ± 7.17 岁，平均受教育年限为 14.42 ± 2.61 年，82.56%为女性。随着时间的推移，西方饮食评分与抑郁症状呈正相关（饮食评分三分位 3 比一分位 1： = 0.22，se = 0.09， = 0.02；趋势 = 0.022）。与性别存在交互作用，表明女性的影响更强。西方饮食与更多卒中后抑郁症状相关，这表明营养不仅对降低脑血管风险很重要，而且对保护卒中后心理健康也很重要。
