Ichimura Yasunori, Yamauchi Masato, Yoshida Naoko, Miyano Shinsuke, Komada Kenichi, Thandar Moe Moe, Tiwara Steven, Mita Toshihiro, Hombhanje Francis W, Mori Yoshio, Takeda Makoto, Hachiya Masahiko
Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan.
Department of Tropical Medicine and Parasitology, Juntendo University, Tokyo, Japan.
IJID Reg. 2022 Mar 3;3:84-88. doi: 10.1016/j.ijregi.2022.03.001. eCollection 2022 Jun.
This study aimed to assess measles and rubella immunity by measuring virus-specific immunoglobulin G (IgG) prevalence among individuals and evaluate the effectiveness of recent supplementary immunization activities (SIAs) by comparing the antibody positivity rates of the SIA target age groups in 2015 with those in 2019 as measles and rubella are endemic in Papua New Guinea.
A cross-sectional study. The measles- and rubella-specific IgG levels of patients aged ≥1 year at two clinics in East Sepik province, Papua New Guinea were assessed with commercially available virus-specific IgG EIA kits.
In total, 297 people participated in the study and 278 samples with sufficient volume, relevant information, and age inclusion criteria were analyzed. The overall IgG prevalence rates were 62.6% for measles and 82.0% for rubella. The age groups targeted in the 2019 SIAs had a higher IgG prevalence than those targeted in the 2015 SIAs for both the infectious diseases. Moreover, the IgG prevalence for rubella was higher than measles in these groups.
The anti-measles and anti-rubella IgG prevalence in the target groups were lower than those required for herd immunity. The immunization program should be emphasized to eliminate measles and rubella. Further population-based studies are warranted.
本研究旨在通过测量个体中病毒特异性免疫球蛋白G（IgG）的流行率来评估麻疹和风疹免疫力，并通过比较2015年和2019年补充免疫活动（SIA）目标年龄组的抗体阳性率，来评估近期补充免疫活动的有效性，因为麻疹和风疹在巴布亚新几内亚为地方病。
一项横断面研究。使用市售的病毒特异性IgG酶免疫分析试剂盒，对巴布亚新几内亚东塞皮克省两家诊所中年龄≥1岁患者的麻疹和风疹特异性IgG水平进行评估。
共有297人参与了该研究，对278份具备足够样本量、相关信息且符合年龄纳入标准的样本进行了分析。麻疹的总体IgG流行率为62.6%，风疹为82.0%。对于这两种传染病，2019年补充免疫活动所针对的年龄组的IgG流行率均高于2015年补充免疫活动所针对的年龄组。此外，在这些年龄组中，风疹的IgG流行率高于麻疹。
目标群体中的抗麻疹和抗风疹IgG流行率低于群体免疫所需水平。应强调免疫规划以消除麻疹和风疹。有必要开展进一步的基于人群的研究。
