麻疹、腮腺炎和风疹：印度年轻人中对疫苗可预防疾病易感性的横断面研究。
Measles, mumps, and rubella: A cross-sectional study of susceptibility to vaccine-preventable diseases among young people in India.
作者信息
Karade Santosh, Sen Sourav, Sashindran V K, Sharma Punita, Kanitkar Madhuri
机构信息
Assistant Professor, Department of Microbiology, Armed Forces Medical College, Pune 411040, India.
Professor & Head, Department of Microbiology, Armed Forces Medical College, Pune 411040, India.
出版信息
Med J Armed Forces India. 2019 Jan;75(1):70-73. doi: 10.1016/j.mjafi.2018.12.010. Epub 2019 Jan 18.
BACKGROUND
Global elimination of vaccine preventable diseases, such as measles, mumps and rubella is a priority. Many countries have reported diminishing of antibody titres against these diseases among young population as immunization coverage of adolescents and adults in not monitored. The objective of this study was to determine the susceptibility against measles, mumps and rubella among young adults.
METHODS
In this cross-sectional study serological evidence of susceptibility to measles, mumps and rubella was determined by qualitative detection of IgG antibody titres by commercially available enzyme linked florescence assay (VIDAS, bioMerieux) in serum samples young adults.
RESULTS
A total of 335 young individuals (mean age: 20.54 ± 1.37 years) participated voluntarily between May 2017 to September 2018, of which 183 (54.63%) were males. Seroprotection against measles, mumps and rubella were 87.16%, 82.69% and 79.10% respectively.
CONCLUSION
Serological surveillance is important to monitor immune status in population. Susceptibility of young adults to measles, mumps, and rubella indicates need for booster vaccination. With the recent launch of measles-rubella vaccination campaign in India, country specific data will be required to plan periodicity of such campaign, which in turn would be based on accumulation of susceptible individuals in a community. Lastly, inclusion of mumps vaccine in the national universal immunization program needs consideration.
背景
全球消除麻疹、腮腺炎和风疹等疫苗可预防疾病是一项优先任务。许多国家报告称，由于未监测青少年和成年人的免疫覆盖率，年轻人群体中针对这些疾病的抗体滴度正在下降。本研究的目的是确定年轻成年人对麻疹、腮腺炎和风疹的易感性。
方法
在这项横断面研究中，通过使用市售酶联荧光测定法（VIDAS，生物梅里埃公司）对年轻成年人血清样本中的IgG抗体滴度进行定性检测，来确定对麻疹、腮腺炎和风疹易感性的血清学证据。
结果
2017年5月至2018年9月期间，共有335名年轻人（平均年龄：20.54±1.37岁）自愿参与，其中183名（54.63%）为男性。对麻疹、腮腺炎和风疹的血清保护率分别为87.16%、82.69%和79.10%。
结论
血清学监测对于监测人群免疫状态很重要。年轻成年人对麻疹、腮腺炎和风疹的易感性表明需要进行加强免疫接种。随着印度近期启动麻疹-风疹疫苗接种运动，需要国家特定数据来规划此类运动的周期，而这又将基于社区中易感个体的积累情况。最后，需要考虑将腮腺炎疫苗纳入国家通用免疫计划。
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