Sabri Ahmed, Li Changzhao, Monika Fnu, Sharma Aproova, Sharma Poonam
Pathology and Laboratory Medicine, Creighton University School of Medicine, Omaha, USA.
Cureus. 2022 May 24;14(5):e25298. doi: 10.7759/cureus.25298. eCollection 2022 May.
Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma. Vaginal adenocarcinomas are most frequently a metastatic lesion, and less commonly, have clear cell histology and occur in young women with diethylstilbestrol (DES) exposure in utero. Due to the limited diagnostic power of immunohistochemistry (IHC) in differentiating primary from metastatic adenocarcinoma of the vagina, clinical and radiological correlation is critical in this scenario. The prognosis of this tumor depends on the patient's age, tumor stage, tumor differentiation, lymph node status, and distant metastasis. Several treatment modalities are present depending on the tumor stage. We present a case of primary adenocarcinoma of the vagina and describe the histopathologic features including the immunoprofile of the tumor and discuss the clinicopathologic features, differential diagnosis, diagnostic challenges, and a brief overview of the literature about age, size, site, immunohistochemical staining, and DES exposure.
肠型腺癌是一种罕见的原发性阴道癌。阴道腺癌最常见的是转移性病变，较少见的是具有透明细胞组织学特征，且发生于子宫内接触过己烯雌酚（DES）的年轻女性。由于免疫组织化学（IHC）在鉴别原发性阴道腺癌与转移性腺癌方面的诊断能力有限，在这种情况下，临床与影像学的相关性至关重要。该肿瘤的预后取决于患者年龄、肿瘤分期、肿瘤分化程度、淋巴结状态及远处转移情况。根据肿瘤分期有多种治疗方式。我们报告一例原发性阴道腺癌病例，描述其组织病理学特征，包括肿瘤的免疫表型，并讨论临床病理特征、鉴别诊断、诊断挑战以及关于年龄、大小、部位、免疫组化染色和DES暴露的文献简要概述。
