Freemyer Benjamin D, Cabala Torres-Carlos A, Patel Anisha B
Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
J Immunother Precis Oncol. 2019 Dec 13;3(1):31-33. doi: 10.4103/JIPO.JIPO_21_19. eCollection 2020 Feb.
Cutaneous mucinoses are a diverse group of diseases that are occasionally seen in the context of an adverse drug reaction. We report the case of a 59-year-old male who presented with an asymptomatic, acneiform rash on his forehead, scalp, nose, upper chest, and upper back that had developed after treatment with erlotinib therapy used in the treatment of metastatic tonsillar sinus squamous cell carcinoma. Biopsy of these lesions demonstrated atypical histology that had features of both follicular mucinosis and myxedema. This histologic phenomenon is a rare drug reaction that has not previously been described in association with erlotinib.
皮肤黏蛋白病是一组多样的疾病，偶尔会在药物不良反应的背景下出现。我们报告了一例59岁男性病例，该患者在接受用于治疗转移性扁桃体窦鳞状细胞癌的厄洛替尼治疗后，前额、头皮、鼻子、上胸部和上背部出现了无症状的痤疮样皮疹。对这些病变进行活检显示出非典型组织学特征，兼具毛囊黏蛋白病和黏液性水肿的特点。这种组织学现象是一种罕见的药物反应，此前尚未有与厄洛替尼相关的描述。
