Department of Head and Neck Comprehensive Radiation Therapy, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.
Dis Markers. 2022 Jun 15;2022:6704347. doi: 10.1155/2022/6704347. eCollection 2022.
To evaluate the effect of standardized nutritional intervention in patients with nasopharyngeal carcinoma receiving radiotherapy complicated with diabetes mellitus and the impact on quality of life.
From January 2019 to December 2020, 100 diabetic patients with nasopharyngeal carcinoma receiving radiotherapy were assessed for eligibility and recruited. They were concurrently and randomly assigned (1 : 1) to receive either conventional nursing (control group) or standardized nutritional intervention (observation group). The outcomes include clinical efficacy and quality of life.
Standardized nutritional intervention was associated with significantly lower levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPBG), and glycated hemoglobin (HbA1c) versus conventional nursing ( < 0.001). The patients given standardized nutritional intervention showed significantly higher hemoglobin (Hb), prealbumin (PA), and albumin (ALB) levels versus those given conventional nursing at 4 weeks after the start of radiotherapy and at the end of radiotherapy ( < 0.001). The two groups showed similar Morisky scores before intervention ( > 0.05). After intervention, the observation group outperformed the control group in terms of treatment compliance ( < 0.05). Standardized nutritional intervention provided patients with a significantly better quality of life versus conventional nursing ( < 0.05). Standardized nutritional intervention was associated with a significantly lower incidence of adverse events and higher nursing satisfaction versus conventional nursing ( < 0.05).
Standardized nutritional intervention for patients with nasopharyngeal carcinoma given radiotherapy complicated with diabetes mellitus can efficiently restore the normal nutritional status of patients, reduce the complications of radiotherapy, and improve the quality of life of patients, so it is worthy of wide clinical application.
评估标准化营养干预对接受放射治疗合并糖尿病的鼻咽癌患者的疗效及对生活质量的影响。
纳入并评估了 2019 年 1 月至 2020 年 12 月期间 100 例接受放射治疗的糖尿病合并鼻咽癌患者的资格，并将其随机（1：1）分配至常规护理（对照组）或标准化营养干预（观察组）。主要结局为临床疗效和生活质量。
与常规护理相比，标准化营养干预可显著降低空腹血糖（FBG）、餐后 2 小时血糖（2hPBG）和糖化血红蛋白（HbA1c）（ < 0.001）。与常规护理相比，接受标准化营养干预的患者在放射治疗开始后 4 周和放射治疗结束时的血红蛋白（Hb）、前白蛋白（PA）和白蛋白（ALB）水平显著升高（ < 0.001）。两组患者干预前的 Morisky 评分相似（ > 0.05）。干预后，观察组的治疗依从性明显优于对照组（ < 0.05）。与常规护理相比，标准化营养干预可显著提高患者的生活质量（ < 0.05）。与常规护理相比，标准化营养干预可显著降低不良反应发生率和提高护理满意度（ < 0.05）。
对接受放射治疗合并糖尿病的鼻咽癌患者进行标准化营养干预，可有效恢复患者的营养状态，降低放射治疗的并发症，提高患者的生活质量，值得广泛应用于临床。
