脾切除术对人体脂质代谢的影响。
The impact of splenectomy on human lipid metabolism.
机构信息
Department of Gastrointestinal Surgery, Atatürk Training and Research Hospital, Izmir, Turkey.
Department of Gastrointestinal Surgery, Inonu University Turgut Ozal Medical Center, Malatya, Turkey.
出版信息
Ups J Med Sci. 2022 Jun 7;127. doi: 10.48101/ujms.v127.8500. eCollection 2022.
BACKGROUND
Splenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism.
METHODS
The data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight patients whose serum lipid values were measured both preoperatively and 1 year after surgery were included in this study.
RESULTS
Significantly higher levels of total cholesterol, low-density lipoprotein (LDL), and non-high-density lipoprotein (HDL) lipid profile were found in the postsplenectomy measurements. However, no significant differences were recorded in levels of triglyceride, HDL, or very-LDL.
CONCLUSION
We determined that splenectomy does impact lipid metabolism, and that the metabolic effects of splenectomy should further be investigated.
背景
脾切除术会影响患者的血液学、免疫学和代谢功能。由于我们对其代谢影响，特别是对脂质代谢的影响了解有限，因此本研究旨在探讨脾切除术对脂质代谢的影响。
方法
回顾性分析了 2009 年至 2019 年间接受脾切除术的 316 名患者的数据。本研究纳入了 38 名术前和术后 1 年均测量血清脂质值的患者。
结果
脾切除术后测量的总胆固醇、低密度脂蛋白（LDL）和非高密度脂蛋白（HDL）脂质谱水平显著升高。然而，甘油三酯、HDL 或极低密度脂蛋白水平没有差异。
结论
我们确定脾切除术确实会影响脂质代谢，脾切除术的代谢影响需要进一步研究。
Zotero 插件