Region Vastmanland - Uppsala University, Centre for Clinical Research, Vastmanland Hospital Vasteras, Västerås, Sweden.
Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden.
Ups J Med Sci. 2022 Jun 10;127. doi: 10.48101/ujms.v127.8261. eCollection 2022.
A variety of non-evidence-based dietary advice on modified fibre and lactose intakes are provided to patients undergoing pelvic radiotherapy to counteract treatment-related bowel symptoms. More knowledge on the nutritional consequences of such advice is needed. This study aimed to explore how advice on modified fibre and lactose intakes during pelvic radiotherapy was associated with nutrient intakes amongst patients with prostate cancer.
A total of 77 Swedish men who underwent radiotherapy (50/2 Gy + boost 20-30 Gy) in 2009-2014 due to prostate cancer were given dietary advice at radiotherapy onset (baseline) and at 4 and 8 weeks after radiotherapy onset, to modify their fibre and lactose intakes. At baseline, the participants completed a food frequency questionnaire (FFQ) and a 24-h dietary recall. At 4 and 8 weeks, the participants completed the FFQ and a 4-day estimated food record.Fibre and lactose intakes were measured by intake scores calculated from the FFQs. Multiple linear regression models were used to analyse associations between intake scores and fibre- and lactose-related nutrients.
In adjusted analyses, there were few significant associations between dietary advice on modified fibre and lactose intakes and observed intakes of fibre- and lactose-related nutrients. A more modified lactose intake was thus associated with a lower intake of calcium ( = 0.041), whilst a more modified fibre intake was associated with a higher value for the change in intake of vitamin C ( = 0.016).
Dietary advice on modified fibre and lactose intake was in most cases not significantly associated with altered nutrient intakes, rather the energy and nutrient intakes were mostly stable during the pelvic radiotherapy. More research is needed on the nutritional consequences of dietary advice on modified fibre and lactose intakes to reach consensus on if they should continue to be provided in the clinic.
为了缓解盆腔放疗相关的肠道症状，向接受盆腔放疗的患者提供了各种基于非证据的膳食纤维和乳糖摄入量的饮食建议。需要更多关于此类建议的营养后果的知识。本研究旨在探讨盆腔放疗期间膳食纤维和乳糖摄入量的建议如何与前列腺癌患者的营养素摄入量相关。
共有 77 名瑞典男性因前列腺癌于 2009-2014 年接受放疗（50/2 Gy+20-30 Gy 增敏放疗），在放疗开始时（基线）和放疗开始后 4 周和 8 周给予饮食建议，以改变他们的膳食纤维和乳糖摄入量。在基线时，参与者完成了食物频率问卷（FFQ）和 24 小时膳食回忆。在 4 周和 8 周时，参与者完成了 FFQ 和 4 天的估计食物记录。膳食纤维和乳糖的摄入量通过 FFQ 计算得出的摄入量得分来衡量。采用多元线性回归模型分析膳食纤维和乳糖相关营养素与摄入得分之间的关系。
在调整分析中，膳食纤维和乳糖摄入量的调整饮食建议与观察到的膳食纤维和乳糖相关营养素的摄入量之间很少有显著关联。更改为乳糖摄入与钙摄入减少有关（=0.041），而更改为膳食纤维摄入与维生素 C 摄入量变化值较高有关（=0.016）。
膳食纤维和乳糖摄入量的调整饮食建议在大多数情况下与营养素摄入量的改变没有显著关联，而是在盆腔放疗期间，能量和营养素摄入量基本稳定。需要进一步研究膳食纤维和乳糖摄入量调整饮食建议的营养后果，以达成是否应继续在临床中提供此类建议的共识。
