The endoplasmic reticulum chaperone BiP: a target for immunogenic cell death inducers?
作者信息
Kepp Oliver, Bezu Lucillia, Kroemer Guido
机构信息
Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.
Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université Institut Universitaire de France, Paris, France.
出版信息
Oncoimmunology. 2022 Jun 21;11(1):2092328. doi: 10.1080/2162402X.2022.2092328. eCollection 2022.
Abstract
摘要
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The endoplasmic reticulum chaperone BiP: a target for immunogenic cell death inducers?内质网伴侣蛋白BiP：免疫原性细胞死亡诱导剂的作用靶点？
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BiP, a major chaperone protein of the endoplasmic reticulum lumen, plays a direct and important role in the storage of the rapidly exchanging pool of Ca2+.BiP是内质网腔的一种主要伴侣蛋白，在快速交换的Ca2+池的储存中起直接且重要的作用。
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本文引用的文献
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Target Profiling of an Iridium(III)-Based Immunogenic Cell Death Inducer Unveils the Engagement of Unfolded Protein Response Regulator BiP.基于铱(III)的免疫原性细胞死亡诱导剂的靶标分析揭示了未折叠蛋白反应调节剂 BiP 的参与。
J Am Chem Soc. 2022 Jun 15;144(23):10407-10416. doi: 10.1021/jacs.2c02435. Epub 2022 Jun 3.
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Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy.试验观察：酪氨酸激酶抑制剂（TKIs）与免疫疗法联合应用。
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Int Rev Cell Mol Biol. 2021;363:1-20. doi: 10.1016/bs.ircmb.2021.03.003. Epub 2021 May 19.
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Endoplasmic reticulum stress signals in the tumour and its microenvironment.肿瘤及其微环境中的内质网应激信号。
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