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"COVID toes": A true viral phenomenon or a diagnosis without a leg to stand on?“新冠脚趾”:一种真实的病毒现象还是毫无依据的诊断?
JAAD Int. 2022 Dec;9:1-6. doi: 10.1016/j.jdin.2022.06.012. Epub 2022 Jun 19.
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Mayo Clin Proc. 2021 Apr;96(4):989-1005. doi: 10.1016/j.mayocp.2021.01.009. Epub 2021 Jan 21.
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Biomedicines. 2024 Apr 20;12(4):913. doi: 10.3390/biomedicines12040913.
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Dermatologic Changes in Experimental Model of Long COVID.长新冠实验模型中的皮肤变化
Microorganisms. 2024 Jan 27;12(2):272. doi: 10.3390/microorganisms12020272.
3
Unmasking the Enigma of the COVID Toe.揭开新冠脚趾之谜。
Cureus. 2023 Nov 11;15(11):e48641. doi: 10.7759/cureus.48641. eCollection 2023 Nov.
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Development of chilblain lesions during the COVID-19 pandemic is strongly associated with cold weather: a retrospective analysis of patients from a single centre in the USA.冻疮样皮损在 COVID-19 大流行期间的发生与寒冷天气密切相关:来自美国单一中心的患者回顾性分析。
Clin Exp Dermatol. 2024 Feb 14;49(3):284-286. doi: 10.1093/ced/llad396.
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Clinical characteristics of COVID-19 associated vasculopathic diseases.新型冠状病毒肺炎相关血管病变疾病的临床特征
Thromb J. 2023 May 25;21(1):61. doi: 10.1186/s12959-023-00504-4.

本文引用的文献

1
Lack of association between pandemic chilblains and SARS-CoV-2 infection.大流行性寒冷性红斑与 SARS-CoV-2 感染之间缺乏关联。
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). doi: 10.1073/pnas.2122090119.
2
Multiple early factors anticipate post-acute COVID-19 sequelae.多种早期因素预示着急性新冠病毒感染后会出现长期新冠症状。
Cell. 2022 Mar 3;185(5):881-895.e20. doi: 10.1016/j.cell.2022.01.014. Epub 2022 Jan 25.
3
Cutaneous findings following COVID-19 vaccination: review of world literature and own experience.接种 COVID-19 疫苗后的皮肤表现:世界文献复习和自身经验。
J Eur Acad Dermatol Venereol. 2022 Feb;36(2):172-180. doi: 10.1111/jdv.17744. Epub 2021 Nov 2.
4
Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreak.COVID-19 疫情期间冻疮样皮损中的 I 型干扰素反应和血管改变。
Br J Dermatol. 2021 Dec;185(6):1176-1185. doi: 10.1111/bjd.20707. Epub 2021 Oct 5.
5
Coronavirus Disease 2019 and Race in Dermatology.新型冠状病毒肺炎与皮肤病学中的种族问题。
Dermatol Clin. 2021 Oct;39(4):569-574. doi: 10.1016/j.det.2021.05.003. Epub 2021 Jul 29.
6
Type I Interferon Signature in Chilblains Following SARS-CoV-2 mRNA Vaccine: A Case Report.新型冠状病毒mRNA疫苗接种后冻疮中的I型干扰素特征:一例报告
Acta Derm Venereol. 2021 Nov 10;101(11):adv00589. doi: 10.2340/00015555-3888.
7
Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation.“长新冠”患病率及其与爱泼斯坦-巴尔病毒再激活关系的调查
Pathogens. 2021 Jun 17;10(6):763. doi: 10.3390/pathogens10060763.
8
"COVID Toes" After mRNA COVID-19 Vaccines.
J Allergy Clin Immunol Pract. 2021 Aug;9(8):3196-3197. doi: 10.1016/j.jaip.2021.05.030. Epub 2021 Jun 20.
9
Epidemiologic Analysis of Chilblains Cohorts Before and During the COVID-19 Pandemic.COVID-19大流行之前及期间冻疮队列的流行病学分析
JAMA Dermatol. 2021 Aug 1;157(8):947-953. doi: 10.1001/jamadermatol.2021.2120.
10
Chilblain-like lesions after BNT162b2 mRNA COVID-19 vaccine: a case report suggesting that 'COVID toes' are due to the immune reaction to SARS-CoV-2.BNT162b2 mRNA新冠疫苗接种后出现冻疮样病变:一例病例报告提示“新冠脚趾”是由对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的免疫反应所致
J Eur Acad Dermatol Venereol. 2021 Oct;35(10):e630-e632. doi: 10.1111/jdv.17451. Epub 2021 Jun 30.

“新冠脚趾”:一种真实的病毒现象还是毫无依据的诊断?

"COVID toes": A true viral phenomenon or a diagnosis without a leg to stand on?

作者信息

Gao Jia C, Huang Alisen, Desai Ankuri, Safai Bijan, Marmon Shoshana

机构信息

Department of Dermatology, New York Medical College, Valhalla, New York.

Department of Dermatology, State University of New York Downstate Health Sciences University, Brooklyn, New York.

出版信息

JAAD Int. 2022 Dec;9:1-6. doi: 10.1016/j.jdin.2022.06.012. Epub 2022 Jun 19.

DOI:10.1016/j.jdin.2022.06.012
PMID:35756912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9213024/
Abstract

"COVID toes" is the colloquial name of chilblain-like lesions thought to be a sequela of COVID-19 infection. Over two years and approximately 300 publications later, this association remains controversial. Here, we summarize key clinical, serological, biological, histological, and immunological evidence that supports and rejects this relationship and discuss alternate theories underlying the pathogenesis of chilblain-like lesions.

摘要

“新冠脚趾”是冻疮样损伤的通俗名称,被认为是新冠病毒感染的后遗症。两年过去了,大约有300篇相关论文发表,但这种关联仍然存在争议。在此,我们总结了支持和反驳这种关系的关键临床、血清学、生物学、组织学和免疫学证据,并讨论了冻疮样损伤发病机制的其他理论。