“新冠脚趾”：一种真实的病毒现象还是毫无依据的诊断？
"COVID toes": A true viral phenomenon or a diagnosis without a leg to stand on?
作者信息
Gao Jia C, Huang Alisen, Desai Ankuri, Safai Bijan, Marmon Shoshana
机构信息
Department of Dermatology, New York Medical College, Valhalla, New York.
Department of Dermatology, State University of New York Downstate Health Sciences University, Brooklyn, New York.
出版信息
JAAD Int. 2022 Dec;9:1-6. doi: 10.1016/j.jdin.2022.06.012. Epub 2022 Jun 19.
Abstract
"COVID toes" is the colloquial name of chilblain-like lesions thought to be a sequela of COVID-19 infection. Over two years and approximately 300 publications later, this association remains controversial. Here, we summarize key clinical, serological, biological, histological, and immunological evidence that supports and rejects this relationship and discuss alternate theories underlying the pathogenesis of chilblain-like lesions.
摘要
“新冠脚趾”是冻疮样损伤的通俗名称，被认为是新冠病毒感染的后遗症。两年过去了，大约有300篇相关论文发表，但这种关联仍然存在争议。在此，我们总结了支持和反驳这种关系的关键临床、血清学、生物学、组织学和免疫学证据，并讨论了冻疮样损伤发病机制的其他理论。
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本文引用的文献
1
Lack of association between pandemic chilblains and SARS-CoV-2 infection.
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). doi: 10.1073/pnas.2122090119.
2
Multiple early factors anticipate post-acute COVID-19 sequelae.
Cell. 2022 Mar 3;185(5):881-895.e20. doi: 10.1016/j.cell.2022.01.014. Epub 2022 Jan 25.
3
Cutaneous findings following COVID-19 vaccination: review of world literature and own experience.
J Eur Acad Dermatol Venereol. 2022 Feb;36(2):172-180. doi: 10.1111/jdv.17744. Epub 2021 Nov 2.
4
Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreak.
Br J Dermatol. 2021 Dec;185(6):1176-1185. doi: 10.1111/bjd.20707. Epub 2021 Oct 5.
5
Coronavirus Disease 2019 and Race in Dermatology.
Dermatol Clin. 2021 Oct;39(4):569-574. doi: 10.1016/j.det.2021.05.003. Epub 2021 Jul 29.
6
Type I Interferon Signature in Chilblains Following SARS-CoV-2 mRNA Vaccine: A Case Report.
Acta Derm Venereol. 2021 Nov 10;101(11):adv00589. doi: 10.2340/00015555-3888.
7
Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation.
Pathogens. 2021 Jun 17;10(6):763. doi: 10.3390/pathogens10060763.
8
"COVID Toes" After mRNA COVID-19 Vaccines.
J Allergy Clin Immunol Pract. 2021 Aug;9(8):3196-3197. doi: 10.1016/j.jaip.2021.05.030. Epub 2021 Jun 20.
9
Epidemiologic Analysis of Chilblains Cohorts Before and During the COVID-19 Pandemic.
JAMA Dermatol. 2021 Aug 1;157(8):947-953. doi: 10.1001/jamadermatol.2021.2120.
10
Chilblain-like lesions after BNT162b2 mRNA COVID-19 vaccine: a case report suggesting that 'COVID toes' are due to the immune reaction to SARS-CoV-2.
J Eur Acad Dermatol Venereol. 2021 Oct;35(10):e630-e632. doi: 10.1111/jdv.17451. Epub 2021 Jun 30.
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