Ganvir Minal N, Parwani Simran R, Chaudhary Dhanashree S, Parwani Rajkumar, Dadlani Himanshu, Vikey Ashok K, Kawadkar Kshipra P, Jaju Nishita S, Armogida Niccoló Giuseppe, Spagnuolo Gianrico
Department of Periodontology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra, India.
Department of Oral Pathology and Microbiology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra, India.
Int J Dent. 2022 Jun 15;2022:6109040. doi: 10.1155/2022/6109040. eCollection 2022.
The current trial aimed to assess and compare the efficacy of neem chip and diode laser as a local drug delivery (LDD) agent as a supplement to phase I periodontal therapy in treatment of localized chronic moderate periodontitis. . Fourteen systemically healthy participants with 4-6 mm deep periodontal pockets at least in three quadrants (with no alveolar bony defect amenable to respective or regenerative osseous surgery, as seen in orthopantomograph) were selected for the trial. One week after phase I therapy, 10% absorbable chip of neem (commercially prepared by staff of a pharmacy college, Sheriguda, India) was placed in the periodontal pocket on one site, and soft tissue diode laser pocket sterilization was performed on the other site of the arch. Remaining one site was considered as a control. Parameters recorded clinically were plaque index (PI), papillary bleeding index (PBI), probing pocket depth (PPD), and relative attachment level (RAL) measured at baseline, 21 day, and one month postoperatively.
Statistically significant improvements were observed in all clinical parameters at one month as compared to baseline for both treatment groups.
Neem chip supplemented with phase I therapy showed best improvement in clinical parameters followed by laser supplemented with phase I therapy in comparison to phase I therapy alone at one month follow-up. . Neem chips are nature's products, affordable without side effects, with a potential to be used as a local drug delivery agent in treating moderate chronic periodontitis.
当前试验旨在评估和比较印楝片与二极管激光作为局部药物递送(LDD)剂的疗效,作为I期牙周治疗的补充,用于治疗局限性慢性中度牙周炎。选择了14名全身健康的参与者,至少在三个象限有4 - 6毫米深的牙周袋(如曲面断层片所示,无适合进行相应或再生性骨手术的牙槽骨缺损)进行试验。在I期治疗一周后,将10%的可吸收印楝片(由印度谢里古达一所药学院的工作人员商业制备)放置在一个部位的牙周袋中,在牙弓的另一个部位进行软组织二极管激光牙周袋消毒。其余一个部位作为对照。临床记录的参数包括基线、术后21天和1个月时测量的菌斑指数(PI)、龈乳头出血指数(PBI)、探诊深度(PPD)和相对附着水平(RAL)。
与基线相比,两个治疗组在术后1个月时所有临床参数均有统计学意义的改善。
在1个月的随访中,与单独的I期治疗相比,I期治疗辅以印楝片在临床参数方面显示出最佳改善,其次是I期治疗辅以激光。印楝片是天然产品,价格低廉且无副作用,有潜力用作治疗中度慢性牙周炎的局部药物递送剂。