Salmerón Diego
Departamento de Ciencias Sociosanitarias, IMIB-Arrixaca, Universidad de Murcia, Murcia, Spain.
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
J Appl Stat. 2021 Apr 9;49(10):2612-2628. doi: 10.1080/02664763.2021.1913105. eCollection 2022.
The models used to describe the kinetics of ruminal degradation are usually nonlinear models where the dependent variable is the proportion of degraded food. The method of least squares is the standard approach used to estimate the unknown parameters but this method can lead to unacceptable predictions. To solve this issue, a beta nonlinear model and the Bayesian perspective is proposed in this article. The application of standard methodologies to obtain prior distributions, such as the Jeffreys prior or the , involves serious difficulties here because this model is a nonlinear non-normal regression model, and the constrained parameters appear in the log-likelihood function through the Gamma function. This paper proposes an objective method to obtain the prior distribution, which can be applied to other models with similar complexity, can be easily implemented in OpenBUGS, and solves the problem of unacceptable predictions. The model is generalized to a larger class of models. The methodology was applied to real data with three models that were compared using the Deviance Information Criterion and the root mean square prediction error. A simulation study was performed to evaluate the coverage of the credible intervals.
用于描述瘤胃降解动力学的模型通常是非线性模型,其中因变量是降解食物的比例。最小二乘法是用于估计未知参数的标准方法,但该方法可能导致不可接受的预测。为了解决这个问题,本文提出了一种贝塔非线性模型和贝叶斯视角。在这里,应用标准方法来获得先验分布,如杰弗里斯先验或其他先验,存在严重困难,因为该模型是非线性非正态回归模型,并且受约束参数通过伽马函数出现在对数似然函数中。本文提出了一种获得先验分布的客观方法,该方法可应用于其他具有类似复杂性的模型,可在OpenBUGS中轻松实现,并解决了不可接受预测的问题。该模型被推广到更大类的模型。该方法应用于实际数据,使用三个模型,并通过偏差信息准则和均方根预测误差进行比较。进行了一项模拟研究以评估可信区间的覆盖率。