Mabeku Laure Brigitte Kouitcheu, Nguefak Lionel Danny Tali, Nintewoue Ghislaine Florice Faujo, Ngemeshe Stanley Ngimgoh, Mengang Jude-Marcel Nzoume Nsope, Ngatcha Ghislaine, Moungo-Ndjole Carole Marlyse Menzy, Talla Paul
Medical Microbiology Laboratory, Department of Microbiology, Faculty of Science University of Yaoundé I Yaoundé Cameroon.
Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang Dschang Cameroon.
JGH Open. 2025 Aug 6;9(8):e70222. doi: 10.1002/jgh3.70222. eCollection 2025 Aug.
The aim of this study was to determine the prevalence of in relation to endoscopic and histopathology features and to find out the correlation between the two diagnostic methods.
Gastroduodenal biopsy specimens were collected from 475 dyspeptic outpatients who attended the Department of Gastroenterology in reference hospitals in Cameroon. The study was approved by the local and national ethical committees on human health research in Cameroon. Informed consent was obtained from all subjects before inclusion. A full endoscopic evaluation of the esophagus, stomach, and duodenum was performed in all patients. Biopsy samples were collected from each participant for detection using histology and rapid urease test. Hematoxylin and eosin stain was used for histomorphological features examination.
was found in 57.89% of the dyspeptic outpatients. In endoscopy, 40.00% of our patients had gastritis, of which 58.42% were infected. Erythematous-exudative gastritis was the most common gastritis type (46.00%) and also the most common gastritis type found among -infected subjects (43.1%). Histologically, chronic gastritis was the most common histological finding recorded (46.11%) and the abnormality with the highest rate of infection (44.00%). The highest rate of infection was found among patients with moderate neutrophil activity (46.18%). Gastritis types were significantly correlated with histological findings ( = 0.016). Endoscopic findings were significantly correlated with neutrophil activity ( = 0.0005).
The current poor correlation observed between endoscopy and histology findings emphasizes the role of histology in the diagnosis of gastroduodenal pathological features in dyspeptic patients in our context.
本研究旨在确定[具体内容缺失]与内镜及组织病理学特征的相关性，并找出两种诊断方法之间的关联。
从喀麦隆参考医院胃肠病科就诊的475名消化不良门诊患者中收集胃十二指肠活检标本。该研究获得了喀麦隆地方和国家人类健康研究伦理委员会的批准。在纳入所有受试者之前均获得了知情同意。对所有患者进行了食管、胃和十二指肠的全面内镜评估。从每位参与者收集活检样本，使用组织学和快速尿素酶试验检测[具体内容缺失]。苏木精和伊红染色用于组织形态学特征检查。
在57.89%的消化不良门诊患者中发现了[具体内容缺失]。在内镜检查中，40.00%的患者患有胃炎，其中58.42%感染了[具体内容缺失]。红斑渗出性胃炎是最常见的胃炎类型（46.00%），也是在感染[具体内容缺失]的受试者中最常见的胃炎类型（43.1%）。组织学上，慢性胃炎是记录到的最常见的组织学发现（46.11%），也是感染[具体内容缺失]率最高的异常情况（44.00%）。在中性粒细胞活性中等的患者中发现了最高的[具体内容缺失]感染率（46.18%）。胃炎类型与组织学发现显著相关（P = 0.016）。内镜检查结果与中性粒细胞活性显著相关（P = 0.0005）。
目前在内镜检查和组织学结果之间观察到的较差相关性强调了在我们这种情况下组织学在消化不良患者胃十二指肠病理特征诊断中的作用。
