Deng Xia, Zhao Li, Guo Chang, Yang Ling, Wang Dong, Li Yanyan, Xia Hong, Wang Chenxi, Cai Zhensheng, Li Lian, Zhao Zhicong, Yuan Guoyue
Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Nov 13;13:4341-4351. doi: 10.2147/DMSO.S283413. eCollection 2020.
We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.
Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR<30 mg/g), microalbuminuria (30≤UACR<300 mg/g), and macroalbuminuria (UACR≥300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.
Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63-3.57)] and microalbuminuria [2.10 (1.60-2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18-2.09)] (<0.001). Importantly, the serum level of asprosin was positively correlated with UACR (=0.304, <0.001), creatinine (=0.157, =0.024), blood urea nitrogen (BUN) (=0.244, <0.001), and negatively with glomerular filtration rate (eGFR) (=-0.159, =0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (<0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37~2.928), <0.001].
Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.
我们检测了血清抑胃肽水平在2型糖尿病（T2DM）患者蛋白尿发生发展中是否起作用，此前尚未对此进行过讨论。
根据尿白蛋白/肌酐比值（UACR），将207例T2DM患者分为正常白蛋白尿（UACR<30 mg/g）、微量白蛋白尿（30≤UACR<300 mg/g）和大量白蛋白尿（UACR≥300 mg/g）的T2DM患者。采用酶联免疫吸附测定法测定血清抑胃肽水平。
相比之下，大量白蛋白尿[2.37（1.63 - 3.57）]和微量白蛋白尿[2.10（1.60 - 2.90）]的T2DM患者组血清抑胃肽水平显著高于正常白蛋白尿组[1.59（1.18 - 2.09）]（<0.001）。重要的是，抑胃肽血清水平与UACR（=0.304，<0.001）、肌酐（=0.157，=0.024）、血尿素氮（BUN）（=0.244，<0.001）呈正相关，与肾小球滤过率（eGFR）呈负相关（=-0.159，=0.022）。此外，多因素逐步回归分析显示，抑胃肽与UACR、BUN、舒张压（DBP）和低密度脂蛋白胆固醇（LDL-C）显著且独立相关（<0.05）。此外，在调整混杂因素后，血清抑胃肽水平与T2DM患者蛋白尿的发生持续且独立相关[比值比（95%可信区间）：2.003（1.37~2.928），<0.001]。
显然，血清抑胃肽水平与T2DM患者的UACR独立相关，这意味着循环抑胃肽可能在糖尿病肾病的发病机制中起重要作用。
