Yang Man, Li Jin, Yang Haidong, Yan Linya, Liu Dongliang, Zhu Lin, Zhang Xiaobin
Department of Psychiatry, The Fourth People's Hospital of Lianyungang, The Affiliated KangDa College of Nanjing Medical University, Lianyungang, China.
Department of Psychiatry, Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Front Psychiatry. 2022 Jun 10;13:896694. doi: 10.3389/fpsyt.2022.896694. eCollection 2022.
The present study aimed to examine whether plasma oxidative stress is associated with cognitive impairment in long term hospitalized patients with chronic schizophrenia.
Ninety-six chronic schizophrenia patients and 94 healthy unaffected subjects were enrolled. Plasma markers of oxidative stress, including malondialdehyde (MDA), manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GSH-Px), were measured. Psychiatric symptoms and cognitive function were assessed with the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), respectively.
Plasma MDA levels and MnSOD and GSH-Px activities were significantly lower in schizophrenia patients than in healthy controls ( < 0.001), while plasma CAT activity was higher than in healthy controls ( < 0.005). Cognitive scores on the RBANS and all of its five subscales (all < 0.001) were significantly lower in schizophrenia patients than in healthy unaffected subjects. CAT and GSH-Px activities were positively correlated with the cognitive function scores corresponding to Visuospatial/Constructional abilities in the patient group ( = 0.298, 0.213, respectively, < 0.05). Also, the multiple regression analysis revealed that CAT and GSH-Px activities were independent and separate contributors to the Visuospatial/Constructional index of the RBANS. Meanwhile, CAT activity was negatively correlated with general pathological symptoms ( = -0.307, Bonferroni corrected = 0.008) and the total score of the PANSS domains ( = -0.299, Bonferroni corrected = 0.012).
Our results that the reduced of MDA level and the increased CAT activity in plasma in male patients with chronic schizophrenia suggest that redox imbalance may be associated with the pathophysiology of schizophrenia, and it can induce impaired cognition and psychiatric symptoms.
本研究旨在探讨长期住院的慢性精神分裂症患者血浆氧化应激是否与认知障碍有关。
招募了96名慢性精神分裂症患者和94名健康对照者。检测了氧化应激的血浆标志物，包括丙二醛（MDA）、锰超氧化物歧化酶（MnSOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）。分别用阳性和阴性症状量表（PANSS）和可重复性神经心理状态评估量表（RBANS）评估精神症状和认知功能。
精神分裂症患者的血浆MDA水平以及MnSOD和GSH-Px活性显著低于健康对照组（<0.001），而血浆CAT活性高于健康对照组（<0.005）。精神分裂症患者的RBANS认知得分及其所有五个子量表得分（均<0.001）均显著低于健康对照者。在患者组中，CAT和GSH-Px活性与视觉空间/构建能力对应的认知功能得分呈正相关（分别为r = 0.298、0.213，均<0.05）。此外，多元回归分析显示，CAT和GSH-Px活性是RBANS视觉空间/构建指数的独立且不同的影响因素。同时，CAT活性与一般病理症状呈负相关（r = -0.307，Bonferroni校正P = 0.008）以及PANSS各领域总分呈负相关（r = -0.299，Bonferroni校正P = 0.012）。
我们的结果表明，慢性精神分裂症男性患者血浆中MDA水平降低和CAT活性升高，提示氧化还原失衡可能与精神分裂症的病理生理学有关，并且可导致认知障碍和精神症状。
