Agrawal Sudhir, Kandimalla Ekambar R
University of Massachusetts Medical School, Department of Medicine, Worcester, USA.
ARNAY Sciences LLC, Shrewsbury, USA.
Immunooncol Technol. 2019 Oct 16;3:15-23. doi: 10.1016/j.iotech.2019.10.001. eCollection 2019 Oct.
Recently, it has become clear that the tumour microenvironment (TME) is important in cancer immunotherapy. While immune checkpoint inhibitors are effective for some patients, the heterogeneous nature and status of the TME ('cold' tumours) play a critical role in suppressing antitumour immunity in non-responding patients. Converting 'cold' to 'hot' tumours through modulation of the TME may enable expansion of the therapeutic efficacy of immunotherapy to a broader patient population. This paper describes advances in intratumoural immunotherapy, specifically activation of nucleic acid sensing pattern recognition receptors to modulate the TME.
最近，肿瘤微环境（TME）在癌症免疫治疗中的重要性已变得清晰。虽然免疫检查点抑制剂对一些患者有效，但TME的异质性和状态（“冷”肿瘤）在抑制无反应患者的抗肿瘤免疫中起关键作用。通过调节TME将“冷”肿瘤转变为“热”肿瘤，可能会使免疫治疗的疗效扩展到更广泛的患者群体。本文描述了肿瘤内免疫治疗的进展，特别是激活核酸传感模式识别受体来调节TME。
