人工肠道及其在家禽中的应用：综述
Artificial gut and the applications in poultry: A review.
作者信息
Sharma Nishchal K, Wu Shu-Biao, Morgan Natalie K, Crowley Tamsyn M
机构信息
School of Environmental and Rural Science, University of New England, Armidale, NSW, 2351, Australia.
Poultry Hub Australia, University of New England, Armidale, NSW, 2351, Australia.
出版信息
Anim Nutr. 2022 Mar 26;10:156-166. doi: 10.1016/j.aninu.2021.12.010. eCollection 2022 Sep.
Artificial gut models including both the gastric and intestinal phases have been used in poultry research for decades to predict the digestibility of nutrients, the efficacy of feed enzymes and additives, and caecal fermentation. However, the models used in the past are static and cannot be used to predict interactions between the feed, gut environment and microbiome. It is imperative that a standard artificial gut model for poultry is established, to enable these interactions to be examined without continual reliance on animals. To ensure the validity of an artificial model, it should be validated with in vivo studies. This review describes current practices in the use of artificial guts in research, their importance in poultry nutrition studies and highlights an opportunity to develop a dynamic gut model for poultry to reduce the number of in vivo experiments.
几十年来，包括胃和肠道阶段的人工肠道模型已被用于家禽研究，以预测养分的消化率、饲料酶和添加剂的功效以及盲肠发酵。然而，过去使用的模型是静态的，无法用于预测饲料、肠道环境和微生物群之间的相互作用。建立一个标准的家禽人工肠道模型势在必行，以便在不持续依赖动物的情况下研究这些相互作用。为确保人工模型的有效性，应通过体内研究对其进行验证。本文综述了人工肠道在研究中的当前应用、它们在家禽营养研究中的重要性，并强调了开发一种动态家禽肠道模型以减少体内实验数量的机会。
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