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通过家禽体外胃肠道模型评估壳聚糖和纤维素聚合物作为结合吸附材料预防黄曲霉毒素B1、伏马菌素B1、赭曲霉毒素、单端孢霉烯族毒素、脱氧雪腐镰刀菌烯醇和玉米赤霉烯酮霉菌毒素中毒的效果。

Evaluation of Chitosan and Cellulosic Polymers as Binding Adsorbent Materials to Prevent Aflatoxin B1, Fumonisin B1, Ochratoxin, Trichothecene, Deoxynivalenol, and Zearalenone Mycotoxicoses Through an In Vitro Gastrointestinal Model for Poultry.

作者信息

Solís-Cruz Bruno, Hernández-Patlán Daniel, Beyssac Eric, Latorre Juan D, Hernandez-Velasco Xochitl, Merino-Guzman Ruben, Tellez Guillermo, López-Arellano Raquel

机构信息

Unidad de Investigación Multidisciplinaria. Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico, Cuautitlán Izcalli, Estado de Mexico 54714, Mexico.

Clermont-Université, Université d'Auvergne, EA4678, Conception Ingénierie et Développement de L'aliment et du Médicament, 63001 Clermont-Ferrand, France.

出版信息

Polymers (Basel). 2017 Oct 19;9(10):529. doi: 10.3390/polym9100529.

DOI:10.3390/polym9100529
PMID:30965830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6418884/
Abstract

Mycotoxins are secondary toxic metabolites that are produced by fungi representing threats to human and animal health. The objective of this study was to evaluate the adsorption capacity of Chitosan (CHI), and three cellulosic polymers (HPMC, CMC, and MCC), on six mycotoxins (AFB₁; FUB₁; OTA; T-2; DON; and, ZEA) using an in vitro digestive model for poultry. The adsorbent capacity of the materials in the supernatant of each compartment was evaluated by a non-competitive chemiluminescent assay. Control groups with no adsorbent material had an adsorption value of 0.00% against all six mycotoxins that were evaluated. All four materials tested showed significant ( < 0.05) binding activity against all of the mycotoxins when compared with the control non-treated group. However HPMC, CMC, and MCC showed better adsorbent capacity when compared with CHI.

摘要

霉菌毒素是由真菌产生的次生毒性代谢产物，对人类和动物健康构成威胁。本研究的目的是使用家禽体外消化模型，评估壳聚糖（CHI）和三种纤维素聚合物（羟丙基甲基纤维素、羧甲基纤维素和微晶纤维素）对六种霉菌毒素（黄曲霉毒素B₁；伏马毒素B₁；赭曲霉毒素A；T-2毒素；脱氧雪腐镰刀菌烯醇；以及玉米赤霉烯酮）的吸附能力。通过非竞争性化学发光测定法评估每个隔室上清液中材料的吸附能力。没有吸附材料的对照组对所有六种评估的霉菌毒素的吸附值为0.00%。与未处理的对照基团相比，所有四种测试材料对所有霉菌毒素均表现出显著（<0.05）的结合活性。然而，与壳聚糖相比，羟丙基甲基纤维素、羧甲基纤维素和微晶纤维素表现出更好的吸附能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3469/6418884/d1464e9f2473/polymers-09-00529-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3469/6418884/d1464e9f2473/polymers-09-00529-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3469/6418884/d1464e9f2473/polymers-09-00529-g001.jpg

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Evaluation of Chitosan and Cellulosic Polymers as Binding Adsorbent Materials to Prevent Aflatoxin B1, Fumonisin B1, Ochratoxin, Trichothecene, Deoxynivalenol, and Zearalenone Mycotoxicoses Through an In Vitro Gastrointestinal Model for Poultry.通过家禽体外胃肠道模型评估壳聚糖和纤维素聚合物作为结合吸附材料预防黄曲霉毒素B1、伏马菌素B1、赭曲霉毒素、单端孢霉烯族毒素、脱氧雪腐镰刀菌烯醇和玉米赤霉烯酮霉菌毒素中毒的效果。
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