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泰国前分析质量倡议对胆管癌诊断的影响。

The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand.

机构信息

Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, Thailand.

Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.

出版信息

Front Public Health. 2022 Jun 10;10:792847. doi: 10.3389/fpubh.2022.792847. eCollection 2022.

DOI:10.3389/fpubh.2022.792847
PMID:35757604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9231639/
Abstract

Cholangiocarcinoma (CCA) is the most prevalent malignancy in Thailand, with unfortunate late diagnosis and frequent metastatic disease outcomes. An accurate tissue diagnosis is the first and most important step in the treatment of CCA. Tissue quality and preservation during the pre-analytical phase play major roles in the proper histological evaluation and potential biomarker testing. This study evaluated the impact of using the "Cholangiocarcinoma Screening and Care Program (CASCAP)" container, as an innovative tool to address pre-analytical challenges faced by pathology laboratories in Thailand. This is a comparison study examining the quality of CCA specimens using the CASCAP container vs. the conventional method, using hematoxylin and eosin (H&E) and immunohistochemistry (IHC). CCA tissue quality using the CASCAP container significantly reduced artifact deposition while improving the cellular structure and nuclear and cytoplasmic morphologies. The immunohistochemical expression of cytokeratin 19 (CK19), a prognostic marker in CCA, significantly improved in the CASCAP container group in comparison with the conventional method. This innovation is proven to significantly enhance the CCA tissue quality diagnostics and prognostic biomarker testing, hence improving overall cancer care, diagnosis, and treatment in Thailand.

摘要

胆管癌（CCA）是泰国最常见的恶性肿瘤，其诊断往往较晚，且常发生转移。准确的组织诊断是治疗 CCA 的第一步，也是最重要的一步。在分析前阶段，组织的质量和保存对正确的组织学评估和潜在的生物标志物检测起着重要作用。本研究评估了使用“胆管癌筛查和护理计划（CASCAP）”容器作为一种创新工具来解决泰国病理实验室在分析前阶段面临的挑战的效果。这是一项对比研究，使用 CASCAP 容器与传统方法（使用苏木精和伊红（H&E）和免疫组织化学（IHC））检查 CCA 标本的质量。与传统方法相比，CASCAP 容器显著减少了人工制品的沉积，同时改善了细胞结构和核质形态。CCA 的预后标志物细胞角蛋白 19（CK19）的免疫组化表达在 CASCAP 容器组中显著改善。这种创新被证明可以显著提高 CCA 组织质量诊断和预后生物标志物检测，从而改善泰国的整体癌症护理、诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/42d0ec90a518/fpubh-10-792847-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/5ea9685d50bf/fpubh-10-792847-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/c992bdfd4cf5/fpubh-10-792847-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/5d3a818d276a/fpubh-10-792847-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/5af62c24fd13/fpubh-10-792847-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/42d0ec90a518/fpubh-10-792847-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/5ea9685d50bf/fpubh-10-792847-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/c992bdfd4cf5/fpubh-10-792847-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/5d3a818d276a/fpubh-10-792847-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/5af62c24fd13/fpubh-10-792847-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f1e/9231639/42d0ec90a518/fpubh-10-792847-g0005.jpg

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Antibody Identification for Antigen Detection in Formalin-Fixed Paraffin-Embedded Tissue Using Phage Display and Naïve Libraries.使用噬菌体展示和天然文库对福尔马林固定石蜡包埋组织中的抗原检测进行抗体鉴定
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