Department of Public Health and Infection Management, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China.
Department of Information Administration, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, China.
Front Public Health. 2022 Jun 9;10:844150. doi: 10.3389/fpubh.2022.844150. eCollection 2022.
To investigate the independent and collective effects of maternal folic acid supplementation or dietary folate intake on the risk of low birth weight (LBW), and to further comprehensively examine the joint associations of folic acid supplementation and dietary folate intake with LBW by various clinical subtypes.
Participants were recruited from Gansu Provincial Maternity and Child Care Hospital. A standardized and structured questionnaire was distributed to collect demographic factors, reproductive and medical history, occupational and residential history, physical activity, and diet. Data on pregnancy-related complications and birth outcomes were extracted from medical records. Unconditional logistic regression models were used to estimate the odds ratio () and 95% confidence interval (95% ) for single and joint associations of folic acid supplementation and dietary folate intake with LBW.
A birth cohort data analysis using the 2010-2012 Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China.
In total, 9,231 pregnant women and their children were enrolled in the study.
Compared with non-users, folic acid supplementation was associated with a reduced risk of LBW (: 0.80, 95% : 0.66-0.97), and the reduced risk was mainly seen for term-LBW (: 0.59, 95% : 0.41-0.85), and multiparous-LBW (: 0.72, 95% : 0.54-0.94). There were no significant associations between dietary folate intake and LBW, and there was no interaction between folic acid supplement and dietary folate intake on LBW.
Our study results indicated that folic acid supplementation was associated with a reduced risk of LBW, and there was no interaction between folic acid supplements and dietary folate intake on LBW.
探讨母体叶酸补充或膳食叶酸摄入对低出生体重（LBW）风险的独立和综合影响，并进一步综合考察叶酸补充和膳食叶酸摄入对不同临床亚型 LBW 的联合关联。
参与者从甘肃省妇幼保健院招募。分发标准化和结构化问卷，以收集人口统计学因素、生殖和医疗史、职业和居住史、体力活动和饮食。从病历中提取与妊娠相关并发症和出生结局的数据。使用非条件逻辑回归模型估计叶酸补充和膳食叶酸摄入与 LBW 的单因素和联合关联的优势比（OR）和 95%置信区间（95%CI）。
在中国兰州的甘肃省妇幼保健院，对 2010-2012 年的出生队列数据进行分析。
共有 9231 名孕妇及其子女参与了研究。
与非使用者相比，叶酸补充与 LBW 的风险降低相关（OR：0.80，95%CI：0.66-0.97），这种降低的风险主要见于足月 LBW（OR：0.59，95%CI：0.41-0.85）和多产 LBW（OR：0.72，95%CI：0.54-0.94）。膳食叶酸摄入与 LBW 之间无显著关联，叶酸补充和膳食叶酸摄入对 LBW 之间也无交互作用。
我们的研究结果表明，叶酸补充与 LBW 的风险降低相关，且叶酸补充和膳食叶酸摄入对 LBW 之间无交互作用。
