Yang Ting, Gu Yan, Wei Xiaoping, Liang Xiaohua, Chen Jie, Liu Youxue, Zhang Ting, Li Tingyu
Children Nutrition Research Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Er Rd, Yuzhong District, Chongqing 400014, China.
Capital Institute of Pediatrics, No. 2 Yabao Er Rd, Chaoyang District, Beijing 100020, China.
J Clin Biochem Nutr. 2017 Mar;60(2):136-142. doi: 10.3164/jcbn.16-45. Epub 2017 Feb 8.
Maternal folate and vitamin B deficiency predict poor pregnancy outcome. To improve pregnancy outcomes in rural area of China, we investigate rural women's folic acid supplementation (FAS) status and the associations between maternal vitamin B status during the first trimester and subsequent adverse pregnancy outcomes. We collected the questionnaire information and drew 5 ml of blood from 309 early pregnant rural women. The birth outcomes were retrieved from medical records after delivery. Out of the total, 257 had taken FAS, including 50 before conception (group A) and 207 during the first trimester (group B). The concentration of plasma folate and the RBC folate supplementation groups were obviously higher than that of no-supplementation group (group N, <0.01). The mean vitamin B levels in FAS group were significantly higher than those in groups N and B (<0.05). Women who delivered SGA or premature infants had reduced plasma folate levels (<0.05) compared with controls. The multiple linear regression models revealed that RBC folate levels affected the infant birth weight (<0.01) and birth length (<0.05). In conclusion, FAS can significantly improve plasma folate and RBC folate levels in childbearing-age women and reduce the risk of subsequent adverse pregnancy outcomes.
母体叶酸和维生素B缺乏预示着不良妊娠结局。为改善中国农村地区的妊娠结局，我们调查了农村妇女的叶酸补充（FAS）状况以及孕早期母体维生素B状况与随后不良妊娠结局之间的关联。我们收集了问卷信息，并从309名早期妊娠的农村妇女中抽取了5毫升血液。分娩后从医疗记录中获取出生结局。总共有257名妇女进行了叶酸补充，其中50名在受孕前（A组），207名在孕早期（B组）。补充叶酸组的血浆叶酸浓度和红细胞叶酸水平明显高于未补充组（N组）（P<0.01）。叶酸补充组的平均维生素B水平显著高于N组和B组（P<0.05）。与对照组相比，分娩出小于胎龄儿或早产儿的妇女血浆叶酸水平降低（P<0.05）。多元线性回归模型显示，红细胞叶酸水平影响婴儿出生体重（P<0.01）和出生身长（P<0.05）。总之，叶酸补充可显著提高育龄妇女的血浆叶酸和红细胞叶酸水平，并降低随后不良妊娠结局的风险。
