Danoff Joshua S, Connelly Jessica J, Morris James P, Perkeybile Allison M
University of Virginia, Department of Psychology, 102 Gilmer Hall, P.O. Box 400400, Charlottesville, VA, 22904, USA.
Compr Psychoneuroendocrinol. 2021 Nov 14;8:100098. doi: 10.1016/j.cpnec.2021.100098. eCollection 2021 Nov.
Oxytocin is a neuropeptide hormone which is involved in regulation of social behavior, stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its binding to the oxytocin receptor, coded for by the gene. Many studies have examined the role of epigenetic regulation of in neurological and behavioral outcomes in both humans and animal models. Here, we review these studies, critically analyze their findings in the context of oxytocin's role as an allostatic hormone, and provide suggestions for future research. We use as a model for how those in the field of psychoneuroendocrinology should perform epigenetic studies in order to maximize both biological relevance and potential for biomarker development.
催产素是一种神经肽激素，参与社会行为、应激反应、肌肉收缩和新陈代谢的调节。催产素信号传导依赖于其与由该基因编码的催产素受体的结合。许多研究已经探讨了该基因的表观遗传调控在人类和动物模型的神经和行为结果中的作用。在这里，我们回顾这些研究，在催产素作为一种应激激素的作用背景下批判性地分析它们的发现，并为未来的研究提供建议。我们以该研究为例，说明心理神经内分泌学领域的研究人员应如何进行表观遗传学研究，以最大限度地提高生物学相关性和生物标志物开发的潜力。
