Department of Pediatrics, New York-Presbyterian Hospital - Weill Cornell Medicine, New York, New York.
Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Pediatrics. 2022 Jul 1;150(1). doi: 10.1542/peds.2021-052369.
To evaluate the effect of grandmother and mother educational attainment on low birth weight (LBW) in children and grandchildren.
The National Longitudinal Study of Adolescent to Adult Health is a multigenerational study that collected survey data from 1994 to 2018. Using this database, we constructed a cohort of 2867 non-Hispanic Black (NHB) and non-Hispanic White (NHW) grandmother-mother-grandchild triads to evaluate how education affects the likelihood of having LBW children and grandchildren, while adjusting for socioeconomic and maternal health factors using multivariable logistic regression.
Similar to previous studies, NHB women were more likely to have LBW descendants compared with NHW women in unadjusted and adjusted analyses. The prevalence of LBW descendants was lower in women with college education, regardless of race. Irrespective of race, mother and grandmother college education was associated with decreased odds of LBW children and grandchildren after adjusting for individual variables. When mother and grandmother education were examined together, and after adjusting for all individual, community, and health variables together, mother college education remained associated with lower odds of LBW (adjusted odds ratio, 0.58; 95% confidence interval, 0.44-0.77). There were no statistically significant differences in these effects between NHW and NHB populations.
Educational attainment in mothers is associated with decreased odds of LBW descendants after adjusting for multiple individual, community, and health covariates, regardless of race. Targeting improvements in education may ameliorate adverse pregnancy outcomes that disproportionately affect minority communities and cause significant lifelong consequences.
评估祖母和母亲受教育程度对孙代低出生体重（LBW）的影响。
全国青少年至成人健康纵向研究是一项多代研究，从 1994 年至 2018 年收集了调查数据。利用该数据库，我们构建了一个由 2867 名非西班牙裔黑人（NHB）和非西班牙裔白人（NHW）祖母-母亲-孙辈三胞胎组成的队列，以评估教育如何影响孙代发生 LBW 的可能性，同时使用多变量逻辑回归调整社会经济和产妇健康因素。
与之前的研究相似，在未调整和调整分析中，与 NHW 女性相比，NHB 女性更有可能生育 LBW 后代。无论种族如何，具有大学学历的女性其 LBW 后代的患病率较低。无论种族如何，母亲和祖母的大学教育与调整个体变量后 LBW 儿童和孙辈的几率降低相关。当同时检查母亲和祖母的教育程度，并在同时调整所有个体、社区和健康变量后，母亲的大学教育与 LBW 几率降低相关（调整后的优势比，0.58；95%置信区间，0.44-0.77）。在 NHW 和 NHB 人群中，这些影响之间没有统计学上的显著差异。
在调整了多个个体、社区和健康协变量后，母亲的受教育程度与 LBW 后代的几率降低相关，无论种族如何。针对教育水平的提高可能会改善那些不成比例地影响少数族裔社区并导致严重终身后果的不良妊娠结局。
