Gloger Elana M, Segerstrom Suzanne C
Department of Psychology, University of Kentucky, Lexington, KY, USA.
Psychol Health. 2024 May;39(5):651-669. doi: 10.1080/08870446.2022.2092104. Epub 2022 Jun 27.
Poor cognition increases risk for negative health outcomes, and this may be explained by associations with systemic inflammation. Previously, amount of repetitive thought (Total RT) interacted with IQ to predict interleukin-6 (IL-6) in older adults. This study continued the investigation of repetitive thought (RT) as an element involved in the effect of cognition on inflammation.
Participants ( = 164) came from the Midlife in the United States Refresher project (M = 45.33, SD = 11.51, ranges = 25-74; 48.2% female; 85% Caucasian). Cognition was assessed via telephone, inflammatory biomarkers (IL-6, C-reactive protein (CRP), and tumour-necrosis factor-alpha (TNF- α)) analysed after blood draw, and RT derived from daily diary data.
Cognition significantly interacted with RT valence ( = .009) to explain CRP after covariate adjustment. Better cognition and more negative RT valence was associated with lower CRP ( = -0.190 [-.387, .008]). Worse cognition and more negative RT valence was associated with higher CRP ( = 0.133 [-.031, .297]). No significant effects were found for IL-6 or TNF-α.
RT may interact with cognition to affect different inflammatory biomarkers. Those with worse cognition may benefit more from skills related to regulating thought than those with better cognition.
认知能力差会增加负面健康结果的风险，这可能与全身炎症有关。此前，重复思维量（总重复思维量）与智商相互作用，可预测老年人的白细胞介素-6（IL-6）。本研究继续探讨重复思维（RT）作为认知对炎症影响所涉及的一个因素。
参与者（n = 164）来自美国中年更新项目（M = 45.33，标准差 = 11.51，范围 = 25 - 74；48.2%为女性；85%为白种人）。通过电话评估认知能力，抽血后分析炎症生物标志物（IL-6、C反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）），并从每日日记数据中得出重复思维。
在进行协变量调整后，认知能力与重复思维效价显著相互作用（p = .009），以解释CRP。更好的认知能力和更消极的重复思维效价与较低的CRP相关（β = -0.190 [-0.387, 0.008]）。较差的认知能力和更消极的重复思维效价与较高的CRP相关（β = 0.133 [-0.031, 0.297]）。未发现IL-6或TNF-α有显著影响。
重复思维可能与认知相互作用，影响不同的炎症生物标志物。认知能力较差的人可能比认知能力较好的人从与调节思维相关的技能中获益更多。
