Pattison A, Eason C T, Bonner F W
Res Commun Chem Pathol Pharmacol. 1987 Mar;55(3):423-6.
The effect of nicotinic acid on the synthesis of arachidonic acid metabolites in human whole blood has been examined by stimulation with exogenous and endogenous arachidonic acid substrate. In both cases there was an increase in the production of 6-ketoprostaglandin F1 alpha which was statistically significant at 10 micrograms ml-1 (p less than 0.01) and 100 micrograms ml-1 (p less than 0.001) with endogenous arachidonic acid. This increase is markedly enhanced at nicotinic acid levels of 1000 and 2000 micrograms ml-1 following stimulation with exogenous arachidonic acid (p less than 0.01).
通过外源性和内源性花生四烯酸底物刺激，研究了烟酸对人全血中花生四烯酸代谢产物合成的影响。在这两种情况下，6-酮前列腺素F1α的产生均有所增加，在内源性花生四烯酸存在时，10微克/毫升（p<0.01）和100微克/毫升（p<0.001）时具有统计学意义。在用外源性花生四烯酸刺激后，烟酸水平为1000和2000微克/毫升时，这种增加显著增强（p<0.01）。
