Stomatology Center of China Japan Friendship Hospital, Beijing, China.
Department of Anesthesia, China Japan Friendship Hospital, Beijing, China.
Sleep Breath. 2023 May;27(2):641-649. doi: 10.1007/s11325-022-02668-1. Epub 2022 Jun 27.
The present meta-analysis aimed to evaluate quantitively the recent scientific evidence regarding the association between obstructive sleep apnea (OSA) and periodontitis.
Databases searched were PubMed, EMBASE, Scopus, and Web of Science. Publications were included according to the inclusion criteria. The following outcomes were evaluated: the prevalence of periodontitis, probing depth (PD), clinical attachment loss (CAL), the percentage of sites with bleeding on probing (BOP), plaque index (PI), and gingival index (GI). The statistical analysis was processed using the software STATA.
Thirteen eligible studies comprising a total of 31,800 patients were included. The meta-analysis showed an increased prevalence of periodontitis in OSA populations compared to controls. Both PD and CAL were increased in OSA populations compared with controls. (Prevalence of periodontitis: OR 2.348; 95%CI 2.221-2.482; PD: SMD = 0.681, 95% CI: 0.062-1.301, Z = 2.61, P = 0.031; CAL: SMD = 0.694, 95% CI: 0.167-1.22, Z = 2.58, P = 0.01). The study also found significantly increased BOP in patients with OSA after heterogeneity was clarified. (SMD = 0.357, 95% CI: 0.079-0.635, Z = 2.52, P = 0.012).
The findings suggest that OSA was associated with an increased prevalence of periodontitis.
本荟萃分析旨在定量评估阻塞性睡眠呼吸暂停（OSA）与牙周炎之间关联的最新科学证据。
检索的数据库包括 PubMed、EMBASE、Scopus 和 Web of Science。根据纳入标准纳入出版物。评估的结果包括：牙周炎的患病率、探诊深度（PD）、临床附着丧失（CAL）、探诊出血的部位百分比（BOP）、菌斑指数（PI）和牙龈指数（GI）。统计分析使用 STATA 软件进行处理。
共纳入了 13 项符合纳入标准的研究，总计 31800 名患者。荟萃分析显示，与对照组相比，OSA 人群中牙周炎的患病率增加。与对照组相比，OSA 人群的 PD 和 CAL 均增加。（牙周炎的患病率：OR 2.348；95%CI 2.221-2.482；PD：SMD = 0.681，95%CI：0.062-1.301，Z = 2.61，P = 0.031；CAL：SMD = 0.694，95%CI：0.167-1.22，Z = 2.58，P = 0.01）。研究还发现，在明确异质性后，OSA 患者的 BOP 显著增加。（SMD = 0.357，95%CI：0.079-0.635，Z = 2.52，P = 0.012）。
这些发现表明 OSA 与牙周炎的患病率增加有关。
