Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, No.139 Middle Renmin road, Changsha, China.
Stomatology Center of China Japan Friendship Hospital, Beijing, China.
BMC Oral Health. 2021 May 10;21(1):250. doi: 10.1186/s12903-021-01603-2.
Systemic sclerosis (SSc) is a multisystem rheumatic disease. Orofacial manifestations are commonly in SSc but maybe usually ignored and overshadowed by other systemic complications. Multiple comparative studies have been conducted to investigate the possible links between SSc and oral manifestations. The present study aimed to investigate the oral health status in patients with SSc.
Pubmed, Embase, Web of Science, and Scopus were searched up to July 2020. Following outcomes were evaluated: Probing depth (PD), Attachment loss (AL), Bleeding on probing (BOP), Number or percentage of Sites with PD ≥ 4 mm, Prevalence of periodontitis, Number of teeth, Decayed Teeth, Missing teeth, Filled teeth, DMFT index, and the interincisal distance. Newcastle-Ottawa Scale (NOS) were applied for quality assessment. The statistical analysis was processed using the software STATA.
11 eligible studies were included. The maximum interincisor distance was significantly restricted in SSc patients (SMD - 1.061; 95 %CI [- 1.546, - 0.576]; Z = 4.29, P = 0.000).The prevalence of Periodontitis (OR 7.007; 95 %CI [3.529, 13.915]; Z = 5.56, P = 0.000), PD (SMD 3.101; 95 %CI [1.374, 4.829]; Z = 3.52, P = 0.000), AL(SMD 2.584; 95 %CI [0.321, 4.846]; Z = 2.24, P = 0.025), sites with PD ≥ 4mm (SMD 2.071 ; 95 %CI [0.267, 3.875]; Z = 2.25, P = 0.024) and the number of decayed teeth (SMD, 0.186; 95 %CI [0.007, 0.365]; Z = 2.04, P = 0.041) were increased significantly in SSc population in comparison with the controls.
SSc patients have limited mouth opening, higher periodontitis prevalence, and worse periodontal status, as well as an increased number of decayed teeth. Routinely oral hygiene instruction and initial periodontal treatment is recommended for SSc patients.
系统性硬化症（SSc）是一种多系统风湿性疾病。口腔表现通常在 SSc 中很常见，但可能经常被其他全身并发症所忽视和掩盖。已经进行了多项比较研究来探讨 SSc 与口腔表现之间的可能联系。本研究旨在调查 SSc 患者的口腔健康状况。
检索了 PubMed、Embase、Web of Science 和 Scopus，截至 2020 年 7 月。评估了以下结果：探诊深度（PD）、附着丧失（AL）、探诊出血（BOP）、PD≥4mm 的位点数量或百分比、牙周炎患病率、牙齿数量、龋齿、缺失牙、补牙、DMFT 指数和切牙间距离。采用纽卡斯尔-渥太华量表（NOS）进行质量评估。统计分析使用 STATA 软件进行。
纳入了 11 项符合条件的研究。SSc 患者的最大切牙间距离明显受限（SMD-1.061；95%CI[-1.546，-0.576]；Z=4.29，P=0.000）。牙周炎患病率（OR 7.007；95%CI[3.529,13.915]；Z=5.56，P=0.000）、PD（SMD 3.101；95%CI[1.374,4.829]；Z=3.52，P=0.000）、AL（SMD 2.584；95%CI[0.321,4.846]；Z=2.24，P=0.025）、PD≥4mm 的位点数量（SMD 2.071；95%CI[0.267,3.875]；Z=2.25，P=0.024）和龋齿数量（SMD，0.186；95%CI[0.007,0.365]；Z=2.04，P=0.041）在 SSc 人群中明显增加。
SSc 患者张口受限、牙周炎患病率较高、牙周状况较差，以及龋齿数量增加。建议对 SSc 患者进行常规口腔卫生指导和初始牙周治疗。
