Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Immun Inflamm Dis. 2022 Jul;10(7):e644. doi: 10.1002/iid3.644.
Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the nucleosome remodeling and deacetylation complex. It has been implicated in gene transcription, DNA damage repair, maintenance of genome stability, and chromatin assembly. Meanwhile, it is highly related to cell cycle progression and the proceeding of malignancy. Most of the previous studies were focused on the function of CHD4 with tumor cells, cancer stem cells, and cancer cells multidrug resistance. Recently, some researchers have explored the CHD4 functions on the development and differentiation of adaptive immune cells, such as T and B lymphocytes. In this review, we will discuss details of CHD4 in lymphocyte differentiation and development, as well as the critical role of CHD4 in the pathogenesis of the autoimmune disease.
染色质解旋酶 DNA 结合蛋白 4（CHD4）是核小体重塑和去乙酰化复合物的 ATP 酶亚基。它参与基因转录、DNA 损伤修复、基因组稳定性维持和染色质组装。同时，它与细胞周期进程和恶性进展高度相关。以前的大多数研究都集中在 CHD4 与肿瘤细胞、癌症干细胞和癌细胞多药耐药性的功能上。最近，一些研究人员探索了 CHD4 在适应性免疫细胞（如 T 和 B 淋巴细胞）的发育和分化中的作用。在这篇综述中，我们将讨论 CHD4 在淋巴细胞分化和发育中的详细作用，以及 CHD4 在自身免疫性疾病发病机制中的关键作用。
