Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Shock. 2022 Jun 1;57(6):161-171. doi: 10.1097/SHK.0000000000001936.
As a global major health problem and a leading cause of death, sepsis is defined as a failure of homeostasis, which is mainly initiated by an infection and followed by sustained excessive inflammation until immune suppression. Despite advances in the identification and management of clinical sepsis, morbidity, and mortality remain high. In addition, clinical trials have failed to yield promising results. In recent years, the mechanism of regulated cell death (RCD) in sepsis has attracted more and more attention, because these dying cells could release a large number of danger signals which contribute to inflammatory responses and exacerbation of sepsis, providing a new direction for us to make treatment strategy. Here we summarize mechanisms of several forms of RCD in sepsis including necroptosis, pyroptosis, ferroptosis. In conclusion, targeting RCD is considered a promising approach to treat sepsis.
作为一个全球性的主要健康问题和主要死亡原因，败血症被定义为体内平衡的失败，主要由感染引发，并随后持续过度炎症，直至免疫抑制。尽管在临床败血症的识别和管理方面取得了进展，但发病率和死亡率仍然很高。此外，临床试验未能取得有希望的结果。近年来，败血症中调节性细胞死亡（RCD）的机制引起了越来越多的关注，因为这些死亡细胞会释放大量危险信号，导致炎症反应和败血症恶化，为我们制定治疗策略提供了新的方向。在这里，我们总结了败血症中几种形式的 RCD 机制，包括坏死性凋亡、细胞焦亡和铁死亡。总之，靶向 RCD 被认为是治疗败血症的一种有前途的方法。
